Home LiteratureArticle Details
PMID: 18406336 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Function, structure and regulation of the vacuolar (H+)-ATPases.

Archives of biochemistry and biophysics ·Vol. 476 ·No. 1 ·2008-08-01 ·Pages 33-42

Jefferies KC, Cipriano DJ, Forgac M

Abstract

The vacuolar ATPases (or V-ATPases) are ATP-driven proton pumps that function to both acidify intracellular compartments and to transport protons across the plasma membrane. Intracellular V-ATPases function in such normal cellular processes as receptor-mediated endocytosis, intracellular membrane traffic, prohormone processing, protein degradation and neurotransmitter uptake, as well as in disease processes, including infection by influenza and other viruses and killing of cells by anthrax and diphtheria toxin. Plasma membrane V-ATPases are important in such physiological processes as urinary acidification, bone resorption and sperm maturation as well as in human diseases, including osteopetrosis, renal tubular acidosis and tumor metastasis. V-ATPases are large multi-subunit complexes composed of a peripheral domain (V(1)) responsible for hydrolysis of ATP and an integral domain (V(0)) that carries out proton transport. Proton transport is coupled to ATP hydrolysis by a rotary mechanism. V-ATPase activity is regulated in vivo using a number of mechanisms, including reversible dissociation of the V(1) and V(0) domains, changes in coupling efficiency of proton transport and ATP hydrolysis and changes in pump density through reversible fusion of V-ATPase containing vesicles. V-ATPases are emerging as potential drug targets in treating a number of human diseases including osteoporosis and cancer.

MeSH Terms
Adenosine Triphosphate/metabolism Cell Membrane/metabolism Humans Ion Transport Protein Subunits/chemistry,physiology Vacuolar Proton-Translocating ATPases/chemistry,physiology
Chemicals
Protein Subunits Adenosine Triphosphate Vacuolar Proton-Translocating ATPases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Jefferies Kevin C
Department of Physiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA.
Cipriano Daniel J
Forgac Michael
References (118)
118 references, click to expand
  1. Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology.
    Nat Rev Mol Cell Biol. 2007 Nov;8(11):917-29 PMID: 17912264
  2. Evidence that the NH2 terminus of vph1p, an integral subunit of the V0 sector of the yeast V-ATPase, interacts directly with the Vma1p and Vma13p subunits of the V1 sector.
    J Biol Chem. 2000 May 19;275(20):15449-57 PMID: 10747882
  3. Photoaffinity labeling of wild-type and mutant forms of the yeast V-ATPase A subunit by 2-azido-[(32)P]ADP.
    J Biol Chem. 1999 Nov 12;274(46):32869-74 PMID: 10551850
  4. Inhibition of vacuolar H(+)-ATPase by disulfide bond formation between cysteine 254 and cysteine 532 in subunit A.
    J Biol Chem. 1994 May 6;269(18):13224-30 PMID: 8175752
  5. From lysosomes to the plasma membrane: localization of vacuolar-type H+ -ATPase with the a3 isoform during osteoclast differentiation.
    J Biol Chem. 2003 Jun 13;278(24):22023-30 PMID: 12672822
  6. Structure and assembly of the yeast V-ATPase.
    J Bioenerg Biomembr. 2003 Aug;35(4):301-12 PMID: 14635776
  7. Cysteine-directed cross-linking to subunit B suggests that subunit E forms part of the peripheral stalk of the vacuolar H+-ATPase.
    J Biol Chem. 2002 Feb 1;277(5):3357-63 PMID: 11724797
  8. Reversible association between the V1 and V0 domains of yeast vacuolar H+-ATPase is an unconventional glucose-induced effect.
    Mol Cell Biol. 1998 Dec;18(12):7064-74 PMID: 9819393
  9. A novel accessory subunit for vacuolar H(+)-ATPase from chromaffin granules.
    J Biol Chem. 1994 Sep 30;269(39):24102-6 PMID: 7929063
  10. Subunit rotation of vacuolar-type proton pumping ATPase: relative rotation of the G and C subunits.
    J Biol Chem. 2003 Jun 27;278(26):23714-9 PMID: 12670943
  11. ClC-5, the chloride channel mutated in Dent's disease, colocalizes with the proton pump in endocytotically active kidney cells.
    Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8075-80 PMID: 9653142
  12. Diploids heterozygous for a vma13Delta mutation in Saccharomyces cerevisiae highlight the importance of V-ATPase subunit balance in supporting vacuolar acidification and silencing cytosolic V1-ATPase activity.
    J Biol Chem. 2007 Mar 16;282(11):8521-32 PMID: 17234635
  13. Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis.
    Gene. 2002 Sep 4;297(1-2):169-77 PMID: 12384298
  14. Arg-735 of the 100-kDa subunit a of the yeast V-ATPase is essential for proton translocation.
    Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12397-402 PMID: 11592980
  15. Skp1 forms multiple protein complexes, including RAVE, a regulator of V-ATPase assembly.
    Nat Cell Biol. 2001 Apr;3(4):384-91 PMID: 11283612
  16. Mutations in the gene encoding B1 subunit of H+-ATPase cause renal tubular acidosis with sensorineural deafness.
    Nat Genet. 1999 Jan;21(1):84-90 PMID: 9916796
  17. Yeast V-ATPase complexes containing different isoforms of the 100-kDa a-subunit differ in coupling efficiency and in vivo dissociation.
    J Biol Chem. 2001 May 25;276(21):17941-8 PMID: 11278748
  18. Molecular characterization of the yeast vacuolar H+-ATPase proton pore.
    J Biol Chem. 2000 Aug 4;275(31):23654-60 PMID: 10825180
  19. Three subunit a isoforms of mouse vacuolar H(+)-ATPase. Preferential expression of the a3 isoform during osteoclast differentiation.
    J Biol Chem. 2000 Mar 24;275(12):8760-5 PMID: 10722719
  20. Expression and function of the mouse V-ATPase d subunit isoforms.
    J Biol Chem. 2003 Nov 21;278(47):46396-402 PMID: 12963731
  21. Activation of lysosomal function during dendritic cell maturation.
    Science. 2003 Feb 28;299(5611):1400-3 PMID: 12610307
  22. Three-dimensional structure of the vacuolar ATPase proton channel by electron microscopy.
    J Biol Chem. 2001 Nov 23;276(47):44064-8 PMID: 11533034
  23. Determinants of the pH of the Golgi complex.
    J Biol Chem. 2000 Jul 14;275(28):21025-32 PMID: 10748071
  24. Direct observation of the rotation of epsilon subunit in F1-ATPase.
    J Biol Chem. 1998 Jul 31;273(31):19375-7 PMID: 9677353
  25. Topography and subunit stoichiometry of the coated vesicle proton pump.
    J Biol Chem. 1988 Jun 25;263(18):8796-802 PMID: 2897963
  26. A novel mechanism for regulation of vacuolar acidification.
    J Biol Chem. 1992 Oct 5;267(28):19769-72 PMID: 1400289
  27. Structural and functional features of yeast V-ATPase subunit C.
    Biochim Biophys Acta. 2006 May-Jun;1757(5-6):297-303 PMID: 16829224
  28. The RAVE complex is essential for stable assembly of the yeast V-ATPase.
    J Biol Chem. 2002 Apr 19;277(16):13831-9 PMID: 11844802
  29. Localization of subunit C (Vma5p) in the yeast vacuolar ATPase by immuno electron microscopy.
    FEBS Lett. 2006 Apr 3;580(8):2006-10 PMID: 16546180
  30. Vacuolar H+-ATPase in human breast cancer cells with distinct metastatic potential: distribution and functional activity.
    Am J Physiol Cell Physiol. 2004 Jun;286(6):C1443-52 PMID: 14761893
  31. Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis.
    Nat Genet. 2000 Jul;25(3):343-6 PMID: 10888887
  32. Peripheral stator of the yeast V-ATPase: stoichiometry and specificity of interaction between the EG complex and subunits C and H.
    Biochemistry. 2005 Dec 6;44(48):15906-14 PMID: 16313193
  33. Diversity of mouse proton-translocating ATPase: presence of multiple isoforms of the C, d and G subunits.
    Gene. 2003 Jan 2;302(1-2):147-53 PMID: 12527205
  34. Mutations in ATP6N1B, encoding a new kidney vacuolar proton pump 116-kD subunit, cause recessive distal renal tubular acidosis with preserved hearing.
    Nat Genet. 2000 Sep;26(1):71-5 PMID: 10973252
  35. The evolution of A-, F-, and V-type ATP synthases and ATPases: reversals in function and changes in the H+/ATP coupling ratio.
    FEBS Lett. 2004 Oct 8;576(1-2):1-4 PMID: 15473999
  36. Gelsolin is a downstream effector of rac for fibroblast motility.
    EMBO J. 1998 Mar 2;17(5):1362-70 PMID: 9482733
  37. Microtubules are involved in glucose-dependent dissociation of the yeast vacuolar [H+]-ATPase in vivo.
    J Biol Chem. 2001 Jul 6;276(27):24855-61 PMID: 11331282
  38. ARF1 regulates pH-dependent COP functions in the early endocytic pathway.
    J Biol Chem. 2000 Mar 17;275(11):8154-60 PMID: 10713138
  39. Involvement of the nonhomologous region of subunit A of the yeast V-ATPase in coupling and in vivo dissociation.
    J Biol Chem. 2004 Nov 19;279(47):48663-70 PMID: 15355963
  40. Reconstitution in vitro of the V1 complex from the yeast vacuolar proton-translocating ATPase. Assembly recapitulates mechanism.
    J Biol Chem. 1997 Jun 27;272(26):16618-23 PMID: 9195975
  41. Vacuolar H+-ATPase binding to microfilaments: regulation in response to phosphatidylinositol 3-kinase activity and detailed characterization of the actin-binding site in subunit B.
    J Biol Chem. 2004 Feb 27;279(9):7988-98 PMID: 14662773
  42. Evidence for rotation of V1-ATPase.
    Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2312-5 PMID: 12598655
  43. Subunit interactions in the clathrin-coated vesicle vacuolar (H(+))-ATPase complex.
    J Biol Chem. 1999 Oct 8;274(41):28909-15 PMID: 10506135
  44. Mechanisms of pathogen entry through the endosomal compartments.
    Nat Rev Mol Cell Biol. 2006 Jul;7(7):495-504 PMID: 16773132
  45. Distinct expression patterns of different subunit isoforms of the V-ATPase in the rat epididymis.
    Biol Reprod. 2006 Jan;74(1):185-94 PMID: 16192400
  46. Differential localization of the vacuolar H+ pump with G subunit isoforms (G1 and G2) in mouse neurons.
    J Biol Chem. 2002 Sep 27;277(39):36296-303 PMID: 12133826
  47. The where, when, and how of organelle acidification by the yeast vacuolar H+-ATPase.
    Microbiol Mol Biol Rev. 2006 Mar;70(1):177-91 PMID: 16524922
  48. Expression of the 56-kDa B2 subunit isoform of the vacuolar H(+)-ATPase in proton-secreting cells of the kidney and epididymis.
    Am J Physiol Cell Physiol. 2004 Jul;287(1):C149-62 PMID: 15013950
  49. Mutational analysis of the non-homologous region of subunit A of the yeast V-ATPase.
    J Biol Chem. 2003 Apr 11;278(15):12985-91 PMID: 12569096
  50. Crystal structure of the regulatory subunit H of the V-type ATPase of Saccharomyces cerevisiae.
    Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7134-9 PMID: 11416198
  51. Rapid acidification of endocytic vesicles containing alpha 2-macroglobulin.
    Cell. 1982 Mar;28(3):643-51 PMID: 6176331
  52. The first putative transmembrane segment of subunit c" (Vma16p) of the yeast V-ATPase is not necessary for function.
    J Biol Chem. 2003 Feb 21;278(8):5821-7 PMID: 12482875
  53. Vacuolar H+-ATPase d2 subunit: molecular characterization, developmental regulation, and localization to specialized proton pumps in kidney and bone.
    J Am Soc Nephrol. 2005 May;16(5):1245-56 PMID: 15800125
  54. Renal vacuolar H+-ATPase.
    Physiol Rev. 2004 Oct;84(4):1263-314 PMID: 15383652
  55. The glycolytic enzyme aldolase mediates assembly, expression, and activity of vacuolar H+-ATPase.
    J Biol Chem. 2004 Mar 5;279(10):8732-9 PMID: 14672945
  56. Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man.
    Cell. 2001 Jan 26;104(2):205-15 PMID: 11207362
  57. The amino-terminal domain of the vacuolar proton-translocating ATPase a subunit controls targeting and in vivo dissociation, and the carboxyl-terminal domain affects coupling of proton transport and ATP hydrolysis.
    J Biol Chem. 2001 Dec 14;276(50):47411-20 PMID: 11592965
  58. The amino-terminal domain of the B subunit of vacuolar H+-ATPase contains a filamentous actin binding site.
    J Biol Chem. 2000 Oct 13;275(41):32331-7 PMID: 10915794
  59. Yeast V1-ATPase: affinity purification and structural features by electron microscopy.
    J Biol Chem. 2003 Nov 21;278(47):47299-306 PMID: 12960158
  60. The vacuolar (H+)-ATPases--nature's most versatile proton pumps.
    Nat Rev Mol Cell Biol. 2002 Feb;3(2):94-103 PMID: 11836511
  61. A model for the structure of subunit a of the Escherichia coli ATP synthase and its role in proton translocation.
    Biochim Biophys Acta. 2000 May 31;1458(2-3):457-66 PMID: 10838058
  62. 3'-O-(4-Benzoyl)benzoyladenosine 5'-triphosphate inhibits activity of the vacuolar (H+)-ATPase from bovine brain clathrin-coated vesicles by modification of a rapidly exchangeable, noncatalytic nucleotide binding site on the B subunit.
    J Biol Chem. 1996 May 31;271(22):12775-82 PMID: 8662754
  63. The V-type H+ ATPase: molecular structure and function, physiological roles and regulation.
    J Exp Biol. 2006 Feb;209(Pt 4):577-89 PMID: 16449553
  64. Stimulus-induced phosphorylation of vacuolar H(+)-ATPase by protein kinase A.
    J Biol Chem. 2007 Nov 16;282(46):33735-33742 PMID: 17872947
  65. Role of Vma21p in assembly and transport of the yeast vacuolar ATPase.
    Mol Biol Cell. 2004 Nov;15(11):5075-91 PMID: 15356264
  66. Cysteine-mediated cross-linking indicates that subunit C of the V-ATPase is in close proximity to subunits E and G of the V1 domain and subunit a of the V0 domain.
    J Biol Chem. 2005 Jul 29;280(30):27896-903 PMID: 15951435
  67. The amino-terminal domain of the E subunit of vacuolar H(+)-ATPase (V-ATPase) interacts with the H subunit and is required for V-ATPase function.
    J Biol Chem. 2002 Oct 11;277(41):38409-15 PMID: 12163484
  68. Building the stator of the yeast vacuolar-ATPase: specific interaction between subunits E and G.
    J Biol Chem. 2004 Sep 24;279(39):40670-6 PMID: 15292229
  69. The V-ATPase subunit C binds to polymeric F-actin as well as to monomeric G-actin and induces cross-linking of actin filaments.
    J Biol Chem. 2005 Jan 14;280(2):1070-6 PMID: 15525650
  70. The role of V-ATPase in neuronal and endocrine systems.
    J Exp Biol. 1992 Nov;172:171-8 PMID: 1362770
  71. PKR1 encodes an assembly factor for the yeast V-type ATPase.
    J Biol Chem. 2006 Oct 20;281(42):32025-35 PMID: 16926153
  72. The v-ATPase V0 subunit a1 is required for a late step in synaptic vesicle exocytosis in Drosophila.
    Cell. 2005 May 20;121(4):607-620 PMID: 15907473
  73. Crystal structure of yeast V-ATPase subunit C reveals its stator function.
    EMBO Rep. 2004 Dec;5(12):1148-52 PMID: 15540116
  74. Cysteine 254 of the 73-kDa A subunit is responsible for inhibition of the coated vesicle (H+)-ATPase upon modification by sulfhydryl reagents.
    J Biol Chem. 1992 Mar 25;267(9):5817-22 PMID: 1532573
  75. Mutations in the CYS4 gene provide evidence for regulation of the yeast vacuolar H+-ATPase by oxidation and reduction in vivo.
    J Biol Chem. 1997 Oct 31;272(44):28149-57 PMID: 9346971
  76. Endocytic recycling.
    Nat Rev Mol Cell Biol. 2004 Feb;5(2):121-32 PMID: 15040445
  77. Mutational analysis of the nucleotide binding sites of the yeast vacuolar proton-translocating ATPase.
    J Biol Chem. 1998 Jan 2;273(1):150-6 PMID: 9417059
  78. Mannose 6-phosphate receptors: new twists in the tale.
    Nat Rev Mol Cell Biol. 2003 Mar;4(3):202-12 PMID: 12612639
  79. Interleukin-1 increases vacuolar-type H+-ATPase activity in murine peritoneal macrophages.
    J Biol Chem. 1996 Jan 26;271(4):2005-11 PMID: 8567651
  80. Structural and functional separation of the N- and C-terminal domains of the yeast V-ATPase subunit H.
    J Biol Chem. 2005 Nov 4;280(44):36978-85 PMID: 16141210
  81. Cysteine scanning mutagenesis of the noncatalytic nucleotide binding site of the yeast V-ATPase.
    J Biol Chem. 2000 Jan 7;275(1):255-60 PMID: 10617613
  82. The a3 isoform of V-ATPase regulates insulin secretion from pancreatic beta-cells.
    J Cell Sci. 2006 Nov 1;119(Pt 21):4531-40 PMID: 17046993
  83. Plasmalemmal vacuolar H+-ATPase is decreased in microvascular endothelial cells from a diabetic model.
    J Cell Physiol. 2004 Nov;201(2):190-200 PMID: 15334654
  84. Phosphatidylinositol 3-kinase-mediated effects of glucose on vacuolar H+-ATPase assembly, translocation, and acidification of intracellular compartments in renal epithelial cells.
    Mol Cell Biol. 2005 Jan;25(2):575-89 PMID: 15632060
  85. Properties of H+-translocating adenosine triphosphatase in vacuolar membranes of SAccharomyces cerevisiae.
    J Biol Chem. 1981 Nov 10;256(21):10859-63 PMID: 6116710
  86. Syntaxin isoform specificity in the regulation of renal H+-ATPase exocytosis.
    J Biol Chem. 2003 May 30;278(22):19791-7 PMID: 12651853
  87. Molecular cloning and expression of three isoforms of the 100-kDa a subunit of the mouse vacuolar proton-translocating ATPase.
    J Biol Chem. 2000 Mar 10;275(10):6824-30 PMID: 10702241
  88. Elucidation of the stator organization in the V-ATPase of Neurospora crassa.
    J Mol Biol. 2005 Jun 10;349(3):659-69 PMID: 15890365
  89. The H subunit (Vma13p) of the yeast V-ATPase inhibits the ATPase activity of cytosolic V1 complexes.
    J Biol Chem. 2000 Jul 14;275(28):21761-7 PMID: 10781598
  90. Crystal structure of a central stalk subunit C and reversible association/dissociation of vacuole-type ATPase.
    Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):59-64 PMID: 14684831
  91. Direct observation of the rotation of F1-ATPase.
    Nature. 1997 Mar 20;386(6622):299-302 PMID: 9069291
  92. RAVE is essential for the efficient assembly of the C subunit with the vacuolar H(+)-ATPase.
    J Biol Chem. 2007 Sep 7;282(36):26185-94 PMID: 17623654
  93. Localization of subunits D, E, and G in the yeast V-ATPase complex using cysteine-mediated cross-linking to subunit B.
    Biochemistry. 2002 Sep 17;41(37):11301-7 PMID: 12220197
  94. Physical interaction between aldolase and vacuolar H+-ATPase is essential for the assembly and activity of the proton pump.
    J Biol Chem. 2007 Aug 24;282(34):24495-503 PMID: 17576770
  95. Trans-complex formation by proteolipid channels in the terminal phase of membrane fusion.
    Nature. 2001 Feb 1;409(6820):581-8 PMID: 11214310
  96. Site-directed mutagenesis of the yeast V-ATPase A subunit.
    J Biol Chem. 1997 May 2;272(18):11750-6 PMID: 9115229
  97. V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway.
    Nat Cell Biol. 2006 Feb;8(2):124-36 PMID: 16415858
  98. Specific sorting of the a1 isoform of the V-H+ATPase a subunit to nerve terminals where it associates with both synaptic vesicles and the presynaptic plasma membrane.
    J Cell Sci. 2003 Dec 1;116(Pt 23):4751-62 PMID: 14600261
  99. Transmembrane topography of the 100-kDa a subunit (Vph1p) of the yeast vacuolar proton-translocating ATPase.
    J Biol Chem. 1999 May 21;274(21):14655-61 PMID: 10329659
  100. Structure of a central stalk subunit F of prokaryotic V-type ATPase/synthase from Thermus thermophilus.
    EMBO J. 2005 Nov 16;24(22):3974-83 PMID: 16281059
  101. A journey from mammals to yeast with vacuolar H+-ATPase (V-ATPase).
    J Bioenerg Biomembr. 2003 Aug;35(4):281-9 PMID: 14635774
  102. Topological characterization of the c, c', and c" subunits of the vacuolar ATPase from the yeast Saccharomyces cerevisiae.
    J Biol Chem. 2004 Sep 17;279(38):39856-62 PMID: 15252052
  103. Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling.
    J Biol Chem. 2003 Dec 5;278(49):49523-9 PMID: 14512417
  104. Cellular environment is important in controlling V-ATPase dissociation and its dependence on activity.
    J Biol Chem. 2007 Aug 24;282(34):24743-51 PMID: 17565997
  105. The B1 subunit of the H+ATPase is a PDZ domain-binding protein. Colocalization with NHE-RF in renal B-intercalated cells.
    J Biol Chem. 2000 Jun 16;275(24):18219-24 PMID: 10748165
  106. The E and G subunits of the yeast V-ATPase interact tightly and are both present at more than one copy per V1 complex.
    J Biol Chem. 2006 Aug 11;281(32):22752-60 PMID: 16774922
  107. The V0-ATPase mediates apical secretion of exosomes containing Hedgehog-related proteins in Caenorhabditis elegans.
    J Cell Biol. 2006 Jun 19;173(6):949-61 PMID: 16785323
  108. STV1 gene encodes functional homologue of 95-kDa yeast vacuolar H(+)-ATPase subunit Vph1p.
    J Biol Chem. 1994 May 13;269(19):14064-74 PMID: 7514599
  109. VMA13 encodes a 54-kDa vacuolar H(+)-ATPase subunit required for activity but not assembly of the enzyme complex in Saccharomyces cerevisiae.
    J Biol Chem. 1993 Aug 25;268(24):18286-92 PMID: 8349704
  110. VMA11 and VMA16 encode second and third proteolipid subunits of the Saccharomyces cerevisiae vacuolar membrane H+-ATPase.
    J Biol Chem. 1997 Feb 21;272(8):4795-803 PMID: 9030535
  111. Three-dimensional structure of the vacuolar ATPase. Localization of subunit H by difference imaging and chemical cross-linking.
    J Biol Chem. 2004 Oct 1;279(40):41942-9 PMID: 15269204
  112. A novel role for subunit C in mediating binding of the H+-V-ATPase to the actin cytoskeleton.
    J Biol Chem. 2003 May 16;278(20):18499-505 PMID: 12606563
  113. Identification of a domain in the V0 subunit d that is critical for coupling of the yeast vacuolar proton-translocating ATPase.
    J Biol Chem. 2006 Oct 6;281(40):30001-14 PMID: 16891312
  114. Structure of the rotor of the V-Type Na+-ATPase from Enterococcus hirae.
    Science. 2005 Apr 29;308(5722):654-9 PMID: 15802565
  115. Site-directed mutagenesis of the yeast V-ATPase B subunit (Vma2p).
    J Biol Chem. 1996 Jan 26;271(4):2018-22 PMID: 8567653
  116. Functions of gelsolin: motility, signaling, apoptosis, cancer.
    Curr Opin Cell Biol. 1999 Feb;11(1):103-8 PMID: 10047530
  117. Modulation of the actin cytoskeleton via gelsolin regulates vacuolar H+-ATPase recycling.
    J Biol Chem. 2005 Mar 4;280(9):8452-63 PMID: 15591047
  118. Arrangement of subunits in the proteolipid ring of the V-ATPase.
    J Biol Chem. 2007 Nov 23;282(47):34058-65 PMID: 17897940
Article Info
Journal
Archives of biochemistry and biophysics
Abbr.
Arch Biochem Biophys
ISSN
1096-0384
DOI
10.1016/j.abb.2008.03.025
Published
2008-08-01
Epub
2008-00-29
Pages
33-42
Language
English
Region
United States
NLM ID
0372430
PMCID
PMC2543942
Subset
IM
Grants
NIGMS NIH HHS · R01 GM034478 · United States
NIDDK NIH HHS · DK07542 · United States
NIGMS NIH HHS · R37 GM034478-23 · United States
NIGMS NIH HHS · GM34478 · United States
NIGMS NIH HHS · R37 GM034478 · United States
NIDDK NIH HHS · T32 DK007542 · United States
External Links
PubMed source DOI: 10.1016/j.abb.2008.03.025 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2