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PMID: 18403330 Published · ppublish English Lecture Research Support, N.I.H., Extramural

Fibrogenesis of parenchymal organs.

Proceedings of the American Thoracic Society ·Vol. 5 ·No. 3 ·2008-04-15 ·Pages 338-42

Kisseleva T, Brenner DA

Abstract

Fibrosis of parenchymal organs is caused by prolonged injury, deregulation of the normal processes of wound healing, and extensive deposition of extracellular matrix (ECM) proteins. The current review will focus on common features of fibrogenesis in parenchymal organs, and will briefly discuss common features and differences in the pathophysiology of fibrosis. Comparison of hepatic, renal, and pulmonary fibrosis has identified several common mechanisms. Common themes include a critical role for the cytokine transforming growth factor beta and the generation of reactive oxygen species. Activated myofibroblasts are the common cell type that produce the excessive fibrous scar and may originate from endogenous cells such as hepatic stellate cells or fibroblasts, from the bone marrow such as fibrocytes, or from the transition of epithelial cells to mesenchymal cells. These concepts open new prospects for multidisciplinary research and the development of new therapies for fibrosis.

MeSH Terms
Collagen/biosynthesis Endothelial Cells/metabolism,physiology Epithelial Cells/metabolism,physiology Extracellular Matrix/metabolism Fibrosis Humans Inflammation Kidney/pathology Liver/pathology Lung/pathology Transforming Growth Factor beta1/biosynthesis Wound Healing
Chemicals
Transforming Growth Factor beta1 Collagen
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Kisseleva Tatiana
Department of Medicine, University of California, San Diego, La Jolla, California, USA.
Brenner David A
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Article Info
Journal
Proceedings of the American Thoracic Society
Abbr.
Proc Am Thorac Soc
ISSN
1546-3222
DOI
10.1513/pats.200711-168DR
Published
2008-04-15
Pages
338-42
Language
English
Region
United States
NLM ID
101203596
PMCID
PMC2645245
Subset
IM
Grants
NIGMS NIH HHS · R01 GM041804 · United States
External Links
PubMed source DOI: 10.1513/pats.200711-168DR PMC Full Text
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