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PMID: 18391961 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years.

Nature medicine ·Vol. 14 ·No. 5 ·2008-05-00 ·Pages 507-9

Mendez I, Viñuela A, Astradsson A, Mukhida K, Hallett P, Robertson H, Tierney T, Holness R, Dagher A, Trojanowski JQ, Isacson O

Abstract

Postmortem analysis of five subjects with Parkinson's disease 9-14 years after transplantation of fetal midbrain cell suspensions revealed surviving grafts that included dopamine and serotonin neurons without pathology. These findings are important for the understanding of the etiopathogenesis of midbrain dopamine neuron degeneration and future use of cell replacement therapies.

MeSH Terms
Brain Tissue Transplantation/methods,pathology Fetal Tissue Transplantation/methods,pathology Humans Immunohistochemistry Male Middle Aged Neurons/pathology Parkinson Disease/diagnostic imaging,therapy Positron-Emission Tomography Treatment Outcome Tyrosine 3-Monooxygenase
Chemicals
Tyrosine 3-Monooxygenase
Authors & Affiliations
11 authors, click to expand affiliations / ORCID
Mendez Ivar
Dalhousie University and Queen Elizabeth II Health Sciences Centre, Division of Neurosurgery and Department of Anatomy & Neurobiology, 1976 Summer Street, Halifax, Nova Scotia B3H 3A7, Canada.
Viñuela Angel
Astradsson Arnar
Mukhida Karim
Hallett Penelope
Robertson Harold
Tierney Travis
Holness Renn
Dagher Alain
Trojanowski John Q
Isacson Ole
References (14)
14 references, click to expand
  1. Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats.
    Brain. 2007 Jul;130(Pt 7):1819-33 PMID: 17452372
  2. Differential expression and distribution of alpha-, beta-, and gamma-synuclein in the developing human substantia nigra.
    Exp Neurol. 2001 Apr;168(2):347-55 PMID: 11259122
  3. Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease.
    Brain. 2005 Jul;128(Pt 7):1498-510 PMID: 15872020
  4. Markers and methods for cell sorting of human embryonic stem cell-derived neural cell populations.
    Stem Cells. 2007 Sep;25(9):2257-68 PMID: 17588935
  5. Molecular pathogenesis of Parkinson disease.
    Arch Neurol. 2005 Mar;62(3):353-7 PMID: 15767499
  6. Toward full restoration of synaptic and terminal function of the dopaminergic system in Parkinson's disease by stem cells.
    Ann Neurol. 2003;53 Suppl 3:S135-46; discussion S146-8 PMID: 12666105
  7. Transplantation of embryonic dopamine neurons for severe Parkinson's disease.
    N Engl J Med. 2001 Mar 8;344(10):710-9 PMID: 11236774
  8. The cellular pathology of Parkinson's disease.
    Neuropathology. 2001 Dec;21(4):315-22 PMID: 11837539
  9. Derivation of midbrain dopamine neurons from human embryonic stem cells.
    Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12543-8 PMID: 15310843
  10. Morphogenesis of Lewy bodies: dissimilar incorporation of alpha-synuclein, ubiquitin, and p62.
    J Neuropathol Exp Neurol. 2003 Dec;62(12):1241-53 PMID: 14692700
  11. A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease.
    Ann Neurol. 2003 Sep;54(3):403-14 PMID: 12953276
  12. Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.
    Am J Pathol. 1998 Apr;152(4):879-84 PMID: 9546347
  13. Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes.
    Nat Med. 2006 Nov;12(11):1259-68 PMID: 17057709
  14. Serotonin neuron transplants exacerbate L-DOPA-induced dyskinesias in a rat model of Parkinson's disease.
    J Neurosci. 2007 Jul 25;27(30):8011-22 PMID: 17652591
Article Info
Journal
Nature medicine
Abbr.
Nat Med
ISSN
1546-170X
DOI
10.1038/nm1752
Published
2008-05-00
Epub
2008-00-06
Pages
507-9
Language
English
Region
United States
NLM ID
9502015
PMCID
PMC2656682
Subset
IM
Grants
NINDS NIH HHS · P50 NS053488 · United States
NINDS NIH HHS · NS 053488 · United States
NINDS NIH HHS · P50 NS039793 · United States
NINDS NIH HHS · P50 NS039793-08 · United States
NINDS NIH HHS · P50 NS 39793 · United States
Corrections
CommentIn
PMID: 18463652
External Links
PubMed source DOI: 10.1038/nm1752 PMC Full Text View journal details
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