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PMID: 1839094 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Sequences of four previously undescribed human T-cell receptor beta chain variable genes.

Tissue antigens ·Vol. 38 ·No. 3 ·1991-09-00 ·Pages 99-103

Hansen T, Qvigstad E, Lundin KE, Thorsby E

Abstract

T-cell receptor beta chain mRNA from 4 human T-lymphocyte clones was reverse transcribed, amplified by PCR, cloned in M13 and sequenced. Four hitherto undescribed variable genes were found. One of them (V beta-IW22) showed the highest homology (74.5%) to V beta 1. Two others (V beta-IW6 and V beta-IW10) belonged to the recently described V beta 21 family. The last gene (V beta-VW114) belonged to the V beta 9 family. However, the latter gene a is pseudogene because of an in-frame stop codon.

Related Genes

MeSH Terms

Amino Acid Sequence Base Sequence Clone Cells Genes Humans Molecular Sequence Data Receptors, Antigen, T-Cell, alpha-beta/genetics T-Lymphocytes

Chemicals

Receptors, Antigen, T-Cell, alpha-beta

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Hansen T

Institute of Transplantation Immunology, National Hospital, Oslo, Norway.

Qvigstad E

Lundin K E

Thorsby E

Article Info

Journal

Tissue antigens

Abbr.

Tissue Antigens

ISSN

0001-2815

DOI

10.1111/j.1399-0039.1991.tb02020.x

Published

1991-09-00

Pages

99-103

Language

English

Region

England

NLM ID

0331072

Subset

External Links

PubMed source DOI: 10.1111/j.1399-0039.1991.tb02020.x View journal details

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Sequences of four previously undescribed human T-cell receptor beta chain variable genes.

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