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题目:: Niche regulation of muscle satellite cell self-renewal and differentiation.
作者:: Kuang(Shihuan),Gillespie(Mark A),Rudnicki(Michael A)
状态:: 发布时间2008-03-28 , 更新时间 2016-05-18
期刊:: Cell Stem Cell
摘要:: Muscle satellite cells have been shown to be a heterogeneous population of committed myogenic progenitors and noncommitted stem cells. This hierarchical composition of differentiating progenitors and self-renewable stem cells assures the extraordinary regenerative capacity of skeletal muscles. Recent studies have revealed a role for asymmetric division in satellite cell maintenance and offer novel insights into the regulation of satellite cell function by the niche. A thorough understanding of the molecular regulation and cell fate determination of satellite cells and other potential stem cells resident in muscle is essential for successful stem cell-based therapies to treat muscular diseases.
语言:: eng
DOI:: 10.1016/j.stem.2007.12.012

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