Thrombopoietin, HSCs, and the osteoblast niche: holding on loosely, but not letting G0.
作者:
Emerson(Stephen G)
状态:
发布时间2008-03-28
, 更新时间 2016-11-24
期刊:
Cell Stem Cell
摘要:
New findings in this issue of Cell Stem Cell by Qian et al. (2007) and Yoshihara et al. (2007) reveal that thrombopoietin modulates hematopoietic stem cell (HSC) cell-cycle progression at the osteoblast surface, linking a single cytokine with a specific postnatal niche cell. These observations indicate that simultaneous stimulation and suspension in a G(0) state are critical for maintenance of the HSC pool.