Sic transit gloria: farewell to the epidermal transit amplifying cell?
作者:
Jones(Philip H),Simons(Benjamin D),Watt(Fiona M)
状态:
发布时间2008-03-28
, 更新时间 2016-11-22
期刊:
Cell Stem Cell
摘要:
For the past 30 years, the prevailing model of epidermal homeostasis has been that epidermal stem cells give rise to transit amplifying cells, which undergo a limited number of cell divisions before initiating terminal differentiation. Recent studies challenge the existence of a transit amplifying cell compartment and suggest a new paradigm for epidermal homeostasis.