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PMID: 18366965 Published · ppublish English Journal Article Review

Reversible posterior leukoencephalopathy syndrome in cancer.

Current oncology reports ·Vol. 10 ·No. 1 ·2008-01-00 ·Pages 86-91

Vaughn C, Zhang L, Schiff D

Abstract

Reversible posterior leukoencephalopathy syndrome (RPLS) is a subacute neurological syndrome typically manifesting with headache, cortical blindness, and seizures. The syndrome is associated with risk factors such as malignant hypertension, eclampsia, and renal failure. Numerous case reports depict its occurrence in cancer patients. The direct causal relationship for the mechanism of RPLS in cancer patients has not yet been defined. Cytotoxic chemotherapy may cause direct endothelium damage, which would impact the blood-brain barrier. Chemotherapies also cause elevations in blood pressure; this is significant because RPLS onset may be solely related to hypertension. An increased number of case reports involving new targeted agents suggests that RPLS incidence may increase in the future. Agents such as bevacizumab and sorafenib have been implicated in new cases of RPLS.

MeSH Terms
Humans Neoplasms/complications Posterior Leukoencephalopathy Syndrome/diagnosis,etiology,therapy
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Vaughn Christopher
Division of Hematology/Oncology, University of Virginia Health System, PO Box 800716, Charlottesville, VA 22908, USA. cnv4b@virginia.edu
Zhang Louann
Schiff David
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Article Info
Journal
Current oncology reports
Abbr.
Curr Oncol Rep
ISSN
1534-6269
DOI
10.1007/s11912-008-0013-z
Email
cnv4b@virginia.edu
Published
2008-01-00
Pages
86-91
Language
English
Region
United States
NLM ID
100888967
Subset
IM
External Links
PubMed source DOI: 10.1007/s11912-008-0013-z View journal details
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