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PMID: 18365755 Published · ppublish English Journal Article

Bladder cancer, GSTs, NAT1, NAT2, SULT1A1, XRCC1, XRCC3, XPD genetic polymorphisms and coffee consumption: a case-control study.

European journal of epidemiology ·Vol. 23 ·No. 5 ·2008-00-00 ·Pages 355-62

Covolo L, Placidi D, Gelatti U, Carta A, Scotto Di Carlo A, Lodetti P, Piccichè A, Orizio G, Campagna M, Arici C, Porru S

Abstract

The aim of the study was to investigate NAT1, NAT2, GSTM1, GSTT1, GSTP1, SULT1A1, XRCC1, XRCC3 and XPD genetic polymorphisms, coffee consumption and risk of bladder cancer (BC) through a hospital-based case-control study. The study population included 197 incident BC cases and 211 controls. The association between genetic polymorphisms, coffee drinking and BC risk was assessed by logistic regression taking into account age, education, tobacco smoking and occupational exposures to polycyclic aromatic hydrocarbons and aromatic amines. No association was found between the genetic polymorphisms investigated and BC risk according to coffee consumption apart of a significant increased BC risk among GSTP1 105-114 Val carriers heavy coffee drinkers (>3 cups/day) (OR 3.18, 95% CI 1.06-9.55). In conclusion our findings suggest a very limited role, if any, of genetic polymorphisms investigated in modulating the BC risk in coffee drinkers.

MeSH Terms
Adult Aged Aged, 80 and over Case-Control Studies Coffee Confidence Intervals Diet Female Humans Logistic Models Male Middle Aged Odds Ratio Polymorphism, Genetic/genetics Risk Factors Socioeconomic Factors Urinary Bladder Neoplasms/genetics
Chemicals
Coffee
Authors & Affiliations
11 authors, click to expand affiliations / ORCID
Covolo Loredana
Department of Experimental and Applied Medicine, Institute of Hygiene, Epidemiology and Public Health, University of Brescia, Viale Europa 11, 25123 Brescia, Italy. covolo@med.unibs.it
Placidi Donatella
Gelatti Umberto
Carta Angela
Scotto Di Carlo Antonio
Lodetti Paolo
Piccichè Antonio
Orizio Grazia
Campagna Marcello
Arici Cecilia
Porru Stefano
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Article Info
Journal
European journal of epidemiology
Abbr.
Eur J Epidemiol
ISSN
0393-2990
DOI
10.1007/s10654-008-9238-2
Email
covolo@med.unibs.it
Published
2008-00-00
Pages
355-62
Language
English
Region
Netherlands
NLM ID
8508062
Subset
IM
External Links
PubMed source DOI: 10.1007/s10654-008-9238-2 View journal details
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