Abstract
SWI/SNF, an evolutionarily conserved ATP-dependent chromatin-remodeling complex, has an important role in transcriptional regulation. In Saccharomyces cerevisiae, SWI/SNF regulates the expression of approximately 6% of total genes through activation or repression. Swi1, a subunit of SWI/SNF, contains an N-terminal region rich in glutamine and asparagine, a notable feature shared by all characterized yeast prions--a group of unique proteins capable of self-perpetuating changes in conformation and function. Here we provide evidence that Swi1 can become a prion, [SWI+]. Swi1 aggregates in [SWI+] cells but not in nonprion cells. Cells bearing [SWI+] show a partial loss-of-function phenotype of SWI/SNF. [SW+] can be eliminated by guanidine hydrochloride treatment, HSP104 deletion or loss of Swi1. Moreover, we show [SWI+] is dominantly and cytoplasmically transmitted. Our findings reveal a novel mechanism of 'protein-only' inheritance that results in modification of chromatin-remodeling and, ultimately, global gene regulation.
MeSH Terms
Chromatin Assembly and Disassembly/physiology
Chromosomal Proteins, Non-Histone/genetics,metabolism,physiology
Cytoplasm/metabolism
DNA-Binding Proteins/genetics,metabolism
Epigenesis, Genetic
Genes, Dominant
Guanidine/pharmacology
Heat-Shock Proteins/genetics,metabolism
NIMA-Interacting Peptidylprolyl Isomerase
Peptidylprolyl Isomerase/genetics,metabolism
Prions/physiology
Saccharomyces cerevisiae/genetics,metabolism
Saccharomyces cerevisiae Proteins/genetics,metabolism,physiology
Transcription Factors/genetics,metabolism,physiology
Chemicals
Chromosomal Proteins, Non-Histone
DNA-Binding Proteins
Heat-Shock Proteins
NIMA-Interacting Peptidylprolyl Isomerase
Prions
SNF5 protein, S cerevisiae
SWI1 protein, S cerevisiae
Saccharomyces cerevisiae Proteins
Transcription Factors
HsP104 protein, S cerevisiae
ESS1 protein, S cerevisiae
Peptidylprolyl Isomerase
Guanidine
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Du Zhiqiang
Department of Molecular Pharmacology and Biological Chemistry, The Feinberg School of Medicine, Northwestern University, Searle 5-474, 320 East Superior Street, Chicago, Illinois 60611, USA.
Park Kyung-Won
Yu Haijing
Fan Qing
Li Liming
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