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题目:: Effects of bestatin (Ubenimex) on human T-cell colony formation.
作者:: Wakabayashi(Y),Hashimoto(M),Saitoh(K),Osawa(H),Koike(M),Hirose(S)
状态:: 发布时间1992-01-08 , 更新时间 2013-11-21
期刊:: Anticancer Drugs
摘要:: The antitumor action of bestatin is considered to be an indirect action mediated by T-cells. Therefore, we investigated the effects of bestatin on the differentiation and proliferation of human precursor T-cells using a colony formation technique. Bestatin did not increase the overall number of T-cell colonies, but it significantly increased in CD4+ cell and significantly decreased in CD8+ cell subpopulations. It also induced CD4+.8+ cells. These findings indicated that bestatin acts on precursor T-cells to induce the differentiation of these cells into CD4+ cells.
语言:: eng
DOI:

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