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PMID: 18347975 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Anti-oligosaccharide antibodies as tools for studying sulfated sialoglycoconjugate ligands for siglecs and selectins.

Glycoconjugate journal ·Vol. 26 ·No. 8 ·2009-11-00 ·Pages 923-8

Kannagi R, Ohmori K, Kimura N

Abstract

Several sulfated sialoglycoconjugates have recently been shown to serve as ligands for selectins and siglecs. For instance, alpha2-->3 sialylated 6-sulfo-Lewis x was found to serve as a ligand for selectins on skin-homing helper memory T cells, and alpha2-->6 sialylated 6-sulfo-LacNAc to be a preferred ligand for CD22/siglec-2 on human naïve B cells. Monoclonal antibodies specific to sulfated sialoglycoconjugates are effective tools to dissect these ligands on minor subsets of human leukocytes.

MeSH Terms
Antibodies, Monoclonal/immunology Antibody Specificity/immunology B-Lymphocytes/immunology Biochemistry/methods Glycoconjugates/immunology Humans Lectins/immunology Ligands N-Acetylneuraminic Acid/immunology Oligosaccharides/immunology Selectins/immunology Sialic Acid Binding Immunoglobulin-like Lectins Sulfates/immunology T-Lymphocytes/immunology
Chemicals
Antibodies, Monoclonal Glycoconjugates Lectins Ligands Oligosaccharides Selectins Sialic Acid Binding Immunoglobulin-like Lectins Sulfates N-Acetylneuraminic Acid
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kannagi Reiji
Department of Molecular Pathology, Research Institute, Aichi Cancer Center, 1-1 Kanokoden, Chikusaku, Nagoya 464-8681, Japan. rkannagi@aichi-cc.jp
Ohmori Katsuyuki
Kimura Naoko
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Article Info
Journal
Glycoconjugate journal
Abbr.
Glycoconj J
ISSN
1573-4986
DOI
10.1007/s10719-008-9122-z
Email
rkannagi@aichi-cc.jp
Published
2009-11-00
Pages
923-8
Language
English
Region
United States
NLM ID
8603310
Subset
IM
External Links
PubMed source DOI: 10.1007/s10719-008-9122-z View journal details
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