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PMID: 18342499 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Epidermal Notch signalling: differentiation, cancer and adhesion.

Current opinion in cell biology ·Vol. 20 ·No. 2 ·2008-04-00 ·Pages 171-9

Watt FM, Estrach S, Ambler CA

Abstract

The Notch pathway plays an important role in regulating epidermal differentiation. Notch ligands, receptors and effectors are expressed in a complex and dynamic pattern in embryonic and adult skin. Genetic ablation or activation of the pathway reveals that Notch signalling promotes differentiation of the hair follicle, sebaceous gland and interfollicular epidermal lineages and that Notch acts as an epidermal tumour suppressor. Notch signalling interacts with a range of other pathways to fulfil these functions and acts via RBP-Jkappa dependent and independent mechanisms. The effects on differentiation can be cell autonomous and non-autonomous, and Notch contributes to stem cell clustering via modulation of cell adhesion.

MeSH Terms
Animals Cell Adhesion Cell Differentiation Epidermis/metabolism,pathology Humans Neoplasms/metabolism,pathology Receptors, Notch/metabolism Signal Transduction
Chemicals
Receptors, Notch
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Watt Fiona M
Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK. fiona.watt@cancer.org.uk
Estrach Soline
Ambler Carrie A
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Article Info
Journal
Current opinion in cell biology
Abbr.
Curr Opin Cell Biol
ISSN
0955-0674
DOI
10.1016/j.ceb.2008.01.010
Email
fiona.watt@cancer.org.uk
Published
2008-04-00
Epub
2008-00-14
Pages
171-9
Language
English
Region
England
NLM ID
8913428
PMCID
PMC2324124
Subset
IM
Grants
Wellcome Trust · United Kingdom
NIAMS NIH HHS · F32-AR049651 · United States
NIAMS NIH HHS · F32 AR049651 · United States
Medical Research Council · United Kingdom
Cancer Research UK · United Kingdom
External Links
PubMed source DOI: 10.1016/j.ceb.2008.01.010 PMC Full Text View journal details
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