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PMID: 18328931 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Liver cirrhosis.

Lancet (London, England) ·Vol. 371 ·No. 9615 ·2008-03-08 ·Pages 838-51

Schuppan D, Afdhal NH

Abstract

Cirrhosis is defined as the histological development of regenerative nodules surrounded by fibrous bands in response to chronic liver injury, which leads to portal hypertension and end-stage liver disease. Recent advances in the understanding of the natural history and pathophysiology of cirrhosis, and in treatment of its complications, have resulted in improved management, quality of life, and life expectancy of patients. Liver transplantation remains the only curative option for a selected group of patients, but pharmacological treatments that can halt progression to decompensated cirrhosis or even reverse cirrhosis are currently being developed. This Seminar focuses on the diagnosis, complications, and management of cirrhosis, and new clinical and scientific developments.

MeSH Terms
Animals Carcinoma, Hepatocellular/etiology,mortality,therapy Contraindications Female Humans Liver/anatomy & histology,blood supply Liver Cirrhosis/diagnosis,etiology,physiopathology Liver Neoplasms/etiology,mortality,therapy Liver Transplantation Male
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Schuppan Detlef
Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. dschuppa@bidmc.harvard.edu
Afdhal Nezam H
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Article Info
Journal
Lancet (London, England)
Abbr.
Lancet
ISSN
1474-547X
DOI
10.1016/S0140-6736(08)60383-9
Email
dschuppa@bidmc.harvard.edu
Published
2008-03-08
Pages
838-51
Language
English
Region
England
NLM ID
2985213R
PMCID
PMC2271178
Subset
IM
Grants
NIAID NIH HHS · U19 AI066313-049001 · United States
PHS HHS · U19 A1 066313 · United States
NIAID NIH HHS · U19 AI066313-040003 · United States
NIAID NIH HHS · U19 AI066313-019001 · United States
NIAID NIH HHS · U19 AI066313-010003 · United States
NCCIH NIH HHS · U01 AT003571-02 · United States
NIAID NIH HHS · U19 AI066313-029001 · United States
NCCIH NIH HHS · U01 AT003571 · United States
NIAID NIH HHS · U19 AI066313-039001 · United States
NCCIH NIH HHS · U01 AT003571-01 · United States
NIDDK NIH HHS · 1 R21 DK076873-01A1 · United States
NIAID NIH HHS · U19 AI066313-030003 · United States
NIDDK NIH HHS · R21 DK076873-01A1 · United States
NIAID NIH HHS · U19 AI066313-020003 · United States
External Links
PubMed source DOI: 10.1016/S0140-6736(08)60383-9 PMC Full Text View journal details
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