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PMID: 18321201 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Redox signaling, vascular function, and hypertension.

Antioxidants & redox signaling ·Vol. 10 ·No. 6 ·2008-06-00 ·Pages 1045-59

Lee MY, Griendling KK

Abstract

Accumulating evidence supports the importance of redox signaling in the pathogenesis and progression of hypertension. Redox signaling is implicated in many different physiological and pathological processes in the vasculature. High blood pressure is in part determined by elevated total peripheral vascular resistance, which is ascribed to dysregulation of vasomotor function and structural remodeling of blood vessels. Aberrant redox signaling, usually induced by excessive production of reactive oxygen species (ROS) and/or by decreases in antioxidant activity, can induce alteration of vascular function. ROS increase vascular tone by influencing the regulatory role of endothelium and by direct effects on the contractility of vascular smooth muscle. ROS contribute to vascular remodeling by influencing phenotype modulation of vascular smooth muscle cells, aberrant growth and death of vascular cells, cell migration, and extracellular matrix (ECM) reorganization. Thus, there are diverse roles of the vascular redox system in hypertension, suggesting that the complexity of redox signaling in distinct spatial spectrums should be considered for a better understanding of hypertension.

MeSH Terms
Animals Disease Models, Animal Endothelium, Vascular/metabolism,physiopathology Hypertension/etiology,metabolism,physiopathology Muscle, Smooth, Vascular/metabolism,physiopathology Oxidation-Reduction Rats Reactive Oxygen Species/metabolism Signal Transduction Vasoconstriction Vasodilation
Chemicals
Reactive Oxygen Species
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lee Moo Yeol
Department of Medicine, Division of Cardiology, Emory University, Atlanta, Georgia 30322, USA.
Griendling Kathy K
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Article Info
Journal
Antioxidants & redox signaling
Abbr.
Antioxid Redox Signal
ISSN
1523-0864
DOI
10.1089/ars.2007.1986
Published
2008-06-00
Pages
1045-59
Language
English
Region
United States
NLM ID
100888899
PMCID
PMC2828811
Subset
IM
Grants
NHLBI NIH HHS · HL075209 · United States
NHLBI NIH HHS · P01 HL075209-04 · United States
NHLBI NIH HHS · R01 HL058863 · United States
NHLBI NIH HHS · R01 HL058863-10 · United States
NHLBI NIH HHS · P01 HL058000 · United States
NHLBI NIH HHS · HL058863 · United States
NHLBI NIH HHS · HL58000 · United States
NHLBI NIH HHS · HL38206 · United States
NHLBI NIH HHS · P01 HL075209 · United States
NHLBI NIH HHS · R01 HL038206 · United States
NHLBI NIH HHS · R01 HL038206-18 · United States
NHLBI NIH HHS · P01 HL058000-090001 · United States
External Links
PubMed source DOI: 10.1089/ars.2007.1986 PMC Full Text View journal details
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