Effects of adenosine on adrenergic neurotransmission; prejunctional inhibition and postjunctional enhancement.

Naunyn-Schmiedeberg's archives of pharmacology ·Vol. 293 ·No. 3 ·1976-06-00 ·Pages 217-23

Hedqvist P, Fredholm BB

Abstract

The action of adenosine on adrenergic neuroeffector transmission was studied in the rabbit kidney in vitro and in situ, in the canine subcutaneous adipose tissue in situ and in the guinea pig vas deferens in vitro. In the kidney, adenosine (0.1-10 muM) caused a concentration-dependent increase in vascular resistance and in vasoconstrictor responses to nerve stimulation and administered noradrenaline. In the adipose tissue, adenosine also increased the vaso-constrictor responses but it decreased vascular resistance. In all three tissues studied adenosine significantly and reversibly depressed noradrenaline release evoked by nerve stimulation in a concentration-dependent manner. This effect of adenosine was not altered by phenoxybenzamine which blocked all vasoconstrictor responses and diminished the rise in vascular resistance by adenosine in the kidney. It is concluded that adenosine affects adrenergic neuroeffector transmission by two discrete mechanisms, prejunctional inhibition and postjunctional enhancement.

MeSH Terms

Adenosine/pharmacology Adipose Tissue/blood supply Animals Dogs Electric Stimulation Female Guinea Pigs In Vitro Techniques Kidney/blood supply Male Muscle Contraction/drug effects Neuroeffector Junction/drug effects Norepinephrine/metabolism Phenoxybenzamine/pharmacology Rabbits Regional Blood Flow/drug effects Synaptic Transmission/drug effects Vas Deferens/drug effects Vasomotor System/drug effects

Chemicals

Phenoxybenzamine Adenosine Norepinephrine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Hedqvist P

Fredholm B B

References (21)

21 references, click to expand

Alpha sympathomimetic inhibition of adrenergic and cholinergic transmission in the rabbit heart.
Naunyn Schmiedebergs Arch Pharmacol. 1972;274(1):18-45 PMID: 4403611
Role of pre- and postjunctional inhibition by prostaglandin E2 of lipolysis induced by sympathetic nerve stimulation in dog subcutaneous adipose tissue in situ.
Br J Pharmacol. 1973 Apr;47(4):711-8 PMID: 4723796
Fate of 3H-noradrenaline in canine subcutaneous adipose tissue.
Acta Physiol Scand. 1970 Nov;80(3):404-11 PMID: 5486466
[3H]adenosine triphosphate: release during stimulation of enteric nerves.
Science. 1971 Jul 23;173(3994):336-8 PMID: 4327032
Purinergic nerves.
Pharmacol Rev. 1972 Sep;24(3):509-81 PMID: 4404211
Evidence for prostaglandin mediated prejunctional control of renal sympathetic transmitter release and vascular tone.
Br J Pharmacol. 1975 Jun;54(2):189-96 PMID: 238706
Metabolically linked vasoactive chemicals in local regulation of blood flow.
Physiol Rev. 1968 Oct;48(4):688-707 PMID: 5683736
The effect of adenosine on the release of the transmitter from the phrenic nerve of the rat.
J Physiol. 1972 Aug;224(3):629-45 PMID: 4342002
Release of adenosine-like material from isolated perfused dog adipose tissue following sympathetic nerve stimulation and its inhibition by adrenergic alpha-receptor blockade.
Acta Physiol Scand. 1976 Mar;96(3):122-30 PMID: 179276
ROLE OF CHEMICAL FACTORS IN REGULATION OF FLOW THROUGH KIDNEY, HINDLIMB, AND HEART.
Am J Physiol. 1965 May;208:813-24 PMID: 14286847
Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non-adrenergic inhibitory nerves in the gut.
Br J Pharmacol. 1970 Dec;40(4):668-88 PMID: 4322041
Role of the -adrenoceptor in regulating noradrenaline overflow by nerve stimulation.
Br J Pharmacol. 1972 Apr;44(4):672-88 PMID: 4339385
An enzymatic fluorometric micromethod for the determination of glycerol.
Clin Chim Acta. 1966 Mar;13(3):317-22 PMID: 4287568
Vascular and metabolic effects of theophylline, dibuturyl cyclic AMP and dibuturyl cyclic GMP in canine subcutaneous adipose tissue in situ.
Acta Physiol Scand. 1974 Jan;90(1):226-36 PMID: 4360701
Uptake and metabolism of adenosine by human erythrocyte ghosts.
Am J Physiol. 1972 Jul;223(1):159-66 PMID: 5039059
The effects of adenosine triphosphate and adenosine diphosphate on transmission at the rat and frog neuromuscular junctions.
Br J Pharmacol. 1975 Jun;54(2):213-8 PMID: 167894
Release of free fatty acids from subcutaneous adipose tissue in dogs following sympathetic nerve stimulation.
Acta Physiol Scand. 1966 Jul-Aug;67(3):343-51 PMID: 5967598
Prostaglandin action on noradrenaline release and mechanical responses in the stimulated guinea pig vas deferens.
Acta Physiol Scand. 1974 Jan;90(1):86-93 PMID: 4814547
Adenine derivatives as neurohumoral agents in the brain. The quantities liberated on excitation of superfused cerebral tissues.
Biochem J. 1972 Dec;130(4):975-81 PMID: 4144295
Studies on the effect of prostaglandins E1 and E2 on the sympathetic neuromuscular transmission in some animal tissues.
Acta Physiol Scand Suppl. 1970;345:1-40 PMID: 4325725
Influence of extracellular noradrenaline on the stimulation-evoked secretion of noradrenaline from sympathetic nerves: evidence for an -receptor-mediated feed-back inhibition of noradrenaline release.
Naunyn Schmiedebergs Arch Pharmacol. 1972;275(1):11-23 PMID: 4344328

Article Info

Journal

Naunyn-Schmiedeberg's archives of pharmacology

Abbr.

Naunyn Schmiedebergs Arch Pharmacol

ISSN

0028-1298

DOI

10.1007/BF00507344

Published

1976-06-00

Pages

217-23

Language

English

Region

Germany

NLM ID

0326264

Subset

External Links

PubMed source DOI: 10.1007/BF00507344 View journal details

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Effects of adenosine on adrenergic neurotransmission; prejunctional inhibition and postjunctional enhancement.

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