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PMID: 1830862 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Alpha beta T-lymphocyte depleted mice, a model for gamma delta T-lymphocyte functional studies.

Immunological reviews ·Vol. 120 ·1991-04-00 ·Pages 35-50

Carbone A, Harbeck R, Dallas A, Nemazee D, Finkel T, O'Brien R, Kubo R, Born W

Abstract

Adult mice can be depleted of essentially all mature alpha beta T lymphocytes by chronic treatment with the framework-recognizing, pan-specific anti-TCR alpha beta mAb, H57-597. Similar findings have been reported in rats, gamma delta cell populations remain essentially unaltered in size and reactivity. Suppression of alpha beta T-cell development results in the loss of alloantigen reactivity and of B-cell help, suggesting that gamma delta and alpha beta populations differ in their functional capabilities. Indirect effects of the antibody treatment include quantitative changes in splenic B cells, as well as reduced sizes and weights of experimental animals. alpha beta-suppressed mice and rats may provide model systems for studies on gamma delta cell function in vivo.

MeSH Terms
Animals Antibodies, Monoclonal/immunology Cell Separation Cricetinae Flow Cytometry Lymphocyte Cooperation Lymphocyte Depletion Mice Rats Receptors, Antigen, T-Cell/immunology Receptors, Antigen, T-Cell, alpha-beta Receptors, Antigen, T-Cell, gamma-delta T-Lymphocyte Subsets/immunology Thymus Gland/cytology,growth & development
Chemicals
Antibodies, Monoclonal Receptors, Antigen, T-Cell Receptors, Antigen, T-Cell, alpha-beta Receptors, Antigen, T-Cell, gamma-delta
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Carbone A
Department of Molecular and Cellular Biology, University of California, Berkeley.
Harbeck R
Dallas A
Nemazee D
Finkel T
O'Brien R
Kubo R
Born W
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Article Info
Journal
Immunological reviews
Abbr.
Immunol Rev
ISSN
0105-2896
DOI
10.1111/j.1600-065x.1991.tb00586.x
Published
1991-04-00
Pages
35-50
Language
English
Region
England
NLM ID
7702118
PMCID
PMC4475640
Subset
IM
Grants
NIGMS NIH HHS · R01 GM044809 · United States
NIAID NIH HHS · AI27903-01 · United States
External Links
PubMed source DOI: 10.1111/j.1600-065x.1991.tb00586.x PMC Full Text View journal details
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