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题目:: [Early phase II study of YM 881 (zinostatin stimalamer) by intravenous injection. Research group for intravenous YM 881].
作者:: Saito(T),Nakao(I),Wakui(A),Niitani(H),Kurihara(M),Konno(T),Tsukagoshi(S),Maeda(H)
状态:: 发布时间1991-08-12 , 更新时间 2006-11-15
期刊:: Gan To Kagaku Ryoho
摘要:: An early phase II multicentered study of YM 881 (zinostatin stimalamer) was conducted in 36 patients to investigate response and the safety of the drug in malignant tumors. The response could be evaluated in 18 patients, one with brain tumor, 2 with lung cancer, one with breast cancer, one with liver cancer, one with pancreatic cancer, 6 with gastric cancer, and 6 with colon cancer. PR was found in the patient with brain tumor. Major subjective unwanted effects were gastrointestinal symptoms. Objective evidence of hematological changes (thrombocytopenia, decreased hematocrit, and lymphocytopenia) was also obtained.
语言:: jpn
DOI:

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