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PMID: 18295569 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Capturing pluripotency.

Cell ·Vol. 132 ·No. 4 ·2008-02-22 ·Pages 532-6

Silva J, Smith A

Abstract

In this Essay, we argue that pluripotent epiblast founder cells in the embryo and embryonic stem (ES) cells in culture represent the ground state for a mammalian cell, signified by freedom from developmental specification or epigenetic restriction and capacity for autonomous self-replication. We speculate that cell-to-cell variation may be integral to the ES cell condition, safe-guarding self-renewal while continually presenting opportunities for lineage specification.

MeSH Terms
Animals Cell Lineage Embryo, Mammalian/cytology,metabolism Embryonic Stem Cells/cytology,metabolism Extracellular Signal-Regulated MAP Kinases/metabolism Humans Mice Pluripotent Stem Cells/cytology,metabolism Transcription Factors/metabolism
Chemicals
Transcription Factors Extracellular Signal-Regulated MAP Kinases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Silva Jose
Wellcome Trust Centre for Stem Cell Research and Department of Biochemistry, University of Cambridge, Cambridge CB2 1QR, UK.
Smith Austin
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Article Info
Journal
Cell
Abbr.
Cell
ISSN
1097-4172
DOI
10.1016/j.cell.2008.02.006
Published
2008-02-22
Pages
532-6
Language
English
Region
United States
NLM ID
0413066
PMCID
PMC2427053
Subset
IM
Grants
Medical Research Council · G19/38 · United Kingdom
Wellcome Trust · United Kingdom
Biotechnology and Biological Sciences Research Council · United Kingdom
External Links
PubMed source DOI: 10.1016/j.cell.2008.02.006 PMC Full Text View journal details
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