T-cell development and transmembrane signaling: changing biological responses through an unchanging receptor.

Immunology today ·Vol. 12 ·No. 2 ·1991-02-00 ·Pages 79-85

Finkel TH, Kubo RT, Cambier JC

Abstract

The antigen receptor repertoire is conditioned by discriminating forces in the thymus. Cells that see antigen only in the context of self major histocompatibility gene products are positively selected and those that recognize self antigens are deleted. The molecular mechanisms by which this complex conditioning is achieved via a single antigen receptor is one of the most fascinating problems in immunology. Here Terri Helman Finkel and colleagues review the literature and present a unifying mechanistic model of this process.

MeSH Terms

Animals Antigens, Differentiation, T-Lymphocyte/immunology Autoantigens/immunology CD3 Complex CD4 Antigens/immunology CD8 Antigens Calcium/physiology Cell Differentiation Histocompatibility Antigens/immunology Humans Immune Tolerance Lymphocyte Activation Mice Models, Biological Protein Processing, Post-Translational Protein-Tyrosine Kinases/physiology Proto-Oncogene Proteins/physiology Receptors, Antigen, T-Cell/immunology,physiology Selection, Genetic Signal Transduction T-Lymphocytes/immunology

Chemicals

Antigens, Differentiation, T-Lymphocyte Autoantigens CD3 Complex CD4 Antigens CD8 Antigens Histocompatibility Antigens Proto-Oncogene Proteins Receptors, Antigen, T-Cell Protein-Tyrosine Kinases Calcium

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Finkel T H

National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.

Kubo R T

Cambier J C

Article Info

Journal

Immunology today

Abbr.

Immunol Today

ISSN

0167-5699

DOI

10.1016/0167-5699(91)90162-M

Published

1991-02-00

Pages

79-85

Language

English

Region

England

NLM ID

8008346

Subset

External Links

PubMed source DOI: 10.1016/0167-5699(91)90162-M

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T-cell development and transmembrane signaling: changing biological responses through an unchanging receptor.

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