Linking differential chromatin loops to transcriptional decisions.

Molecular cell ·Vol. 29 ·No. 2 ·2008-02-01 ·Pages 154-6

Apostolou E, Thanos D

Abstract

GATA-1 and GATA-2 control proliferation and differentiation of hematopoietic progenitor cells via transcriptional regulation. In this issue of Molecular Cell, Jing et al. (2008) demonstrate that GATA factor exchange on the Kit locus directs a transcriptional switch by reconfiguring chromatin loops.

MeSH Terms

Animals Cell Line Chromatin/genetics,metabolism Chromatin Assembly and Disassembly/physiology Enhancer Elements, Genetic/physiology Erythropoiesis/physiology GATA1 Transcription Factor/genetics,metabolism GATA2 Transcription Factor/genetics,metabolism Gene Silencing/physiology Mice Nuclear Proteins/genetics,metabolism Proto-Oncogene Proteins c-kit/biosynthesis,genetics Quantitative Trait Loci/physiology Response Elements/physiology Transcription Factors/genetics,metabolism

Chemicals

Chromatin GATA1 Transcription Factor GATA2 Transcription Factor Gata1 protein, mouse Gata2 protein, mouse Nuclear Proteins Transcription Factors Zfpm1 protein, mouse Proto-Oncogene Proteins c-kit

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Apostolou Effie

Institute of Molecular Biology, Genetics and Biotechnology, Biomedical Research Foundation, Academy of Athens, 4 Soranou Efesiou Street, Athens, Greece.

Thanos Dimitris

Article Info

Journal

Molecular cell

Abbr.

Mol Cell

ISSN

1097-2765

DOI

10.1016/j.molcel.2008.01.008

Published

2008-02-01

Pages

154-6

Language

English

Region

United States

NLM ID

9802571

Subset

Corrections

CommentOn

PMID: 18243117

External Links

PubMed source DOI: 10.1016/j.molcel.2008.01.008 View journal details

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Linking differential chromatin loops to transcriptional decisions.

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