Abstract
In a recent issue of Molecular Cell, two independent studies (Zhang et al., 2008; Zhao et al., 2008) provide compelling evidence that targeted deubiquitylation of histones is intimately linked to transcription activation, epigenetic regulation, and cancer progression.
MeSH Terms
Amino Acid Sequence
Animals
Animals, Genetically Modified
Cell Line
Conserved Sequence
Drosophila Proteins/chemistry,genetics,metabolism
Drosophila melanogaster/genetics,metabolism
Endopeptidases/chemistry,genetics,metabolism
Gene Silencing
Heterochromatin/genetics,metabolism
Histone Acetyltransferases/chemistry,genetics,metabolism
Humans
Molecular Sequence Data
Multiprotein Complexes/chemistry,genetics,metabolism
Promoter Regions, Genetic/genetics
Protein Interaction Mapping
RNA Polymerase II/genetics,metabolism
Receptors, Androgen/genetics,metabolism
Recombinant Fusion Proteins/genetics,metabolism
Sequence Alignment
Sequence Homology, Amino Acid
Thiolester Hydrolases/chemistry,physiology
Trans-Activators/chemistry,metabolism
Transcription Factors/chemistry,genetics,metabolism
Transcription Factors, General/chemistry,genetics,metabolism
Transcription, Genetic/physiology
Ubiquitin Thiolesterase
Ubiquitination/physiology
p300-CBP Transcription Factors/chemistry,genetics,metabolism
Chemicals
ATXN7L3 protein, human
Drosophila Proteins
Eny2 protein, human
Heterochromatin
Multiprotein Complexes
Receptors, Androgen
Recombinant Fusion Proteins
Sgf11 protein, Drosophila
Trans-Activators
Transcription Factors
Transcription Factors, General
e(y)2 protein, Drosophila
Histone Acetyltransferases
p300-CBP Transcription Factors
p300-CBP-associated factor
RNA Polymerase II
Thiolester Hydrolases
Endopeptidases
not protein, Drosophila
Ubiquitin Thiolesterase
Usp22 protein, human
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Pijnappel W W M Pim
Department of Physiological Chemistry, STR3.201, University Medical Centre Utrecht, Universiteitsweg 100, Utrecht, The Netherlands.
Timmers H Th Marc