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PMID: 18243090 Published · ppublish English Journal Article Review

Mitochondria--a nexus for aging, calorie restriction, and sirtuins?

Cell ·Vol. 132 ·No. 2 ·2008-01-25 ·Pages 171-6

Guarente L

Abstract

Recent studies of calorie restriction in several organisms demonstrate an increase in mitochondrial activity that is associated with the salutary effects of this dietary restriction regimen. In this Essay, I speculate on how an increase in mitochondrial activity might provide benefit and discuss how diet, mitochondria, and sirtuins might interact in a pathway to slow aging and associated diseases.

MeSH Terms
Aging Animals Caloric Restriction Humans Mitochondria/physiology Models, Biological Sirtuins
Chemicals
Sirtuins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Guarente Leonard
Department of Biology, Massachusetts Institute of Technology, Cambridge MA 02139, USA. leng@mit.edu
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Article Info
Journal
Cell
Abbr.
Cell
ISSN
1097-4172
DOI
10.1016/j.cell.2008.01.007
Email
leng@mit.edu
Published
2008-01-25
Pages
171-6
Language
English
Region
United States
NLM ID
0413066
PMCID
PMC2680180
Subset
IM
Grants
NIA NIH HHS · R01 AG011119 · United States
NIA NIH HHS · R01 AG011119-08 · United States
NIA NIH HHS · R01 AG015339 · United States
NIA NIH HHS · R01 AG015339-04 · United States
External Links
PubMed source DOI: 10.1016/j.cell.2008.01.007 PMC Full Text View journal details
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