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PMID: 18241613 Published · ppublish English Journal Article Review

Genetic determinants of C-reactive protein.

Current atherosclerosis reports ·Vol. 9 ·No. 3 ·2007-09-00 ·Pages 195-203

Danik JS, Ridker PM

Abstract

C-reactive protein (CRP) levels are a complex phenotype with both genetic and environmental determinants. Recent work has highlighted the impact of genetic variants within the CRP gene as well as other candidate genes, often chosen for their role in the inflammatory pathway, on CRP levels. Emerging work shows the association of such genetic variants in CRP not only to CRP levels, but also to variation of CRP levels in the acute phase response. Work on the relation of genetic variants within CRP to cardiovascular disease has had varied results. Whole-genome association studies to investigate the genetic determinants of CRP levels in an unbiased manner are ongoing.

MeSH Terms
Acute Coronary Syndrome/genetics C-Reactive Protein/analysis,genetics Cardiovascular Diseases/genetics Coronary Artery Disease/genetics Genetic Variation Genotype Humans Interleukin-1/physiology Interleukin-6/physiology Phenotype Polymorphism, Genetic Polymorphism, Single Nucleotide/genetics Tumor Necrosis Factor-alpha/physiology
Chemicals
Interleukin-1 Interleukin-6 Tumor Necrosis Factor-alpha C-Reactive Protein
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Danik Jacqueline Suk
Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA. jdanik@partners.org
Ridker Paul M
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Article Info
Journal
Current atherosclerosis reports
Abbr.
Curr Atheroscler Rep
ISSN
1523-3804
DOI
10.1007/s11883-007-0019-2
Email
jdanik@partners.org
Published
2007-09-00
Pages
195-203
Language
English
Region
United States
NLM ID
100897685
Subset
IM
External Links
PubMed source DOI: 10.1007/s11883-007-0019-2 View journal details
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