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PMID: 18206363 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

The termination of translation.

Current opinion in structural biology ·Vol. 18 ·No. 1 ·2008-02-00 ·Pages 70-7

Petry S, Weixlbaumer A, Ramakrishnan V

Abstract

Recent results from cryoelectron microscopy, crystallography, and biochemical experiments have shed considerable light on the process by which protein synthesis is terminated when a stop codon is reached. However, a detailed understanding of the underlying mechanisms will require higher-resolution structures of the various states involved.

MeSH Terms

Amino Acid Sequence Animals Humans Hydrolysis Models, Biological Models, Molecular Molecular Sequence Data Peptide Chain Termination, Translational Peptide Termination Factors/chemistry,metabolism RNA, Transfer, Amino Acyl/chemistry Ribosomal Proteins/chemistry,metabolism Ribosomes/metabolism

Chemicals

Peptide Termination Factors RNA, Transfer, Amino Acyl Ribosomal Proteins ribosome releasing factor tRNA, peptidyl-

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Petry Sabine

MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.

Weixlbaumer Albert

Ramakrishnan V

Article Info

Journal

Current opinion in structural biology

Abbr.

Curr Opin Struct Biol

ISSN

0959-440X

DOI

10.1016/j.sbi.2007.11.005

Published

2008-02-00

Pages

70-7

Language

English

Region

England

NLM ID

9107784

Subset

Grants

Medical Research Council · MC_U105184332 · United Kingdom

External Links

PubMed source DOI: 10.1016/j.sbi.2007.11.005 View journal details

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