Home LiteratureArticle Details
PMID: 18193341 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Inflammatory manifestations in chronic granulomatous disease (CGD).

Journal of clinical immunology ·Vol. 28 Suppl 1 ·2008-05-00 ·Pages S67-72

Rosenzweig SD

Abstract

Chronic granulomatous disease (CGD) is a genetically heterogeneous disease characterized by recurrent life-threatening infections with bacteria and fungi as well as dysregulated inflammatory mechanisms. CGD is caused by defects in the NADPH oxidase, the enzyme complex responsible for generation of superoxide and other reactive oxygen species (ROS) in phagocytic cells. In this review we will focus our attention on those particular inflammatory manifestations associated with CGD, their frequencies and the underlying immunologic mechanisms favoring it occurrence.

MeSH Terms
Autoimmunity/genetics Female Gene Expression Profiling Genes, X-Linked Granulomatous Disease, Chronic/genetics,immunology,physiopathology Humans Inflammation/genetics,immunology Male Mutation NADPH Oxidases/genetics,immunology Phagocytes/immunology
Chemicals
NADPH Oxidases
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Rosenzweig S D
Servicio de Inmunología, Hospital Nacional de Pediatría J. P. Garrahan, Combate de los Pozos 1881, (1245) Buenos Aires, Argentina. srosenzweig@garrahan.gov.ar
References (31)
31 references, click to expand
  1. The urological manifestations of chronic granulomatous disease.
    J Urol. 1992 May;147(5):1314-8 PMID: 1569675
  2. Cytokines in autoimmune disorders.
    Int Rev Immunol. 1998;17(1-4):217-28 PMID: 9914949
  3. Hemophagocytic syndrome and Burkholderia cepacia splenic microabscesses in a child with chronic granulomatous disease.
    Pediatr Infect Dis J. 2004 Sep;23 (9):882-4 PMID: 15361735
  4. Enhanced inflammatory responses of chronic granulomatous disease leukocytes involve ROS-independent activation of NF-kappa B.
    Eur J Immunol. 2007 Apr;37(4):1087-96 PMID: 17330823
  5. Diminished production of anti-inflammatory mediators during neutrophil apoptosis and macrophage phagocytosis in chronic granulomatous disease (CGD).
    J Leukoc Biol. 2003 May;73(5):591-9 PMID: 12714573
  6. Successful treatment of refractory autoimmune thrombocytopenia with rituximab and cyclosporin A in a patient with chronic granulomatous disease.
    Ann Hematol. 2005 Nov;84(12):835-6 PMID: 16078034
  7. Acid aspiration-induced lung inflammation and injury are exacerbated in NADPH oxidase-deficient mice.
    Am J Physiol Lung Cell Mol Physiol. 2007 Mar;292(3):L760-8 PMID: 17114280
  8. Recurrent cystitis and bladder mass in two adults with chronic granulomatous disease.
    Ann Intern Med. 1988 Jul 15;109(2):118-21 PMID: 3289429
  9. Gene expression profiling provides insight into the pathophysiology of chronic granulomatous disease.
    J Immunol. 2004 Jan 1;172(1):636-43 PMID: 14688376
  10. Development of systemic lupus erythematosus in a young child affected with chronic granulomatous disease following withdrawal of treatment with interferon-gamma.
    Rheumatology (Oxford). 2003 Jun;42(6):804-5 PMID: 12771442
  11. Polyarthritis resembling juvenile rheumatoid arthritis in a girl with chronic granulomatous disease.
    Arthritis Rheum. 1994 May;37(5):773-6 PMID: 8185706
  12. Clinical and histopathological features and a unique spectrum of organisms significantly associated with chronic granulomatous disease osteomyelitis during childhood.
    Clin Infect Dis. 2008 Mar 1;46(5):745-9 PMID: 18220479
  13. T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation.
    Nat Immunol. 2004 Aug;5(8):818-27 PMID: 15258578
  14. Successful low toxicity hematopoietic stem cell transplantation for high-risk adult chronic granulomatous disease patients.
    Transplantation. 2005 Jun 15;79(11):1596-606 PMID: 15940051
  15. Ocular pathologic findings of chronic granulomatous disease of childhood.
    Am J Ophthalmol. 1995 Jul;120(1):120-3 PMID: 7611321
  16. Colitis in chronic granulomatous disease.
    Arch Dis Child. 2001 Feb;84(2):147-51 PMID: 11159292
  17. Inhibition of human neutrophil IL-8 production by hydrogen peroxide and dysregulation in chronic granulomatous disease.
    J Immunol. 2005 Jan 1;174(1):411-7 PMID: 15611265
  18. Fulminant mulch pneumonitis: an emergency presentation of chronic granulomatous disease.
    Clin Infect Dis. 2007 Sep 15;45(6):673-81 PMID: 17712749
  19. Gastrointestinal involvement in chronic granulomatous disease.
    Pediatrics. 2004 Aug;114(2):462-8 PMID: 15286231
  20. Chorioretinal lesions in patients and carriers of chronic granulomatous disease.
    J Pediatr. 1999 Jun;134(6):780-3 PMID: 10356152
  21. Chorioretinal lesions in patients with chronic granulomatous disease.
    Retina. 2003 Jun;23(3):360-5 PMID: 12824837
  22. Chronic granulomatous disease. Report on a national registry of 368 patients.
    Medicine (Baltimore). 2000 May;79(3):155-69 PMID: 10844935
  23. Genetic, biochemical, and clinical features of chronic granulomatous disease.
    Medicine (Baltimore). 2000 May;79(3):170-200 PMID: 10844936
  24. Corticosteroids in treatment of obstructive lesions of chronic granulomatous disease.
    J Pediatr. 1987 Sep;111(3):349-52 PMID: 3625401
  25. Patients with chronic granulomatous disease have a reduced peripheral blood memory B cell compartment.
    J Immunol. 2006 Jun 1;176(11):7096-103 PMID: 16709872
  26. Thioglycollate peritonitis in mice lacking C5, 5-lipoxygenase, or p47(phox): complement, leukotrienes, and reactive oxidants in acute inflammation.
    J Leukoc Biol. 2002 Mar;71(3):410-6 PMID: 11867678
  27. Treatment of enteritis in chronic granulomatous disease with granulocyte colony stimulating factor.
    Gut. 1998 Jan;42(1):127-30 PMID: 9505898
  28. Discoid lupus erythematosus-like lesions in carriers of X-linked chronic granulomatous disease.
    Br J Dermatol. 1990 May;122(5):643-50 PMID: 2354117
  29. Cutaneous and other lupus-like symptoms in carriers of X-linked chronic granulomatous disease: incidence and autoimmune serology.
    Clin Exp Immunol. 2007 Apr;148(1):79-84 PMID: 17286762
  30. Corticosteroids for chronic granulomatous disease.
    J Pediatr. 1987 Sep;111(3):393-4 PMID: 3625407
  31. Gastrointestinal complications of chronic granulomatous disease: case report and literature review.
    Clin Pediatr (Phila). 1998 Apr;37(4):231-6 PMID: 9564572
Article Info
Journal
Journal of clinical immunology
Abbr.
J Clin Immunol
ISSN
0271-9142
DOI
10.1007/s10875-007-9160-5
Email
srosenzweig@garrahan.gov.ar
Published
2008-05-00
Epub
2008-00-12
Pages
S67-72
Language
English
Region
Netherlands
NLM ID
8102137
Subset
IM
Grants
FIC NIH HHS · R01TW006644 · United States
External Links
PubMed source DOI: 10.1007/s10875-007-9160-5 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2