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PMID: 18174920 Published · epublish English Journal Article Research Support, Non-U.S. Gov't Review

The mineralocorticoid receptor: insights into its molecular and (patho)physiological biology.

Nuclear receptor signaling ·Vol. 5 ·2007-11-30 ·Pages e012

Viengchareun S, Le Menuet D, Martinerie L, Munier M, Pascual-Le Tallec L, Lombès M

Abstract

The last decade has witnessed tremendous progress in the understanding of the mineralocorticoid receptor (MR), its molecular mechanism of action, and its implications for physiology and pathophysiology. After the initial cloning of MR, and identification of its gene structure and promoters, it now appears as a major actor in protein-protein interaction networks. The role of transcriptional coregulators and the determinants of mineralocorticoid selectivity have been elucidated. Targeted oncogenesis and transgenic mouse models have identified unexpected sites of MR expression and novel roles for MR in non-epithelial tissues. These experimental approaches have contributed to the generation of new cell lines for the characterization of aldosterone signaling pathways, and have also facilitated a better understanding of MR physiology in the heart, vasculature, brain and adipose tissues. This review describes the structure, molecular mechanism of action and transcriptional regulation mediated by MR, emphasizing the most recent developments at the cellular and molecular level. Finally, through insights obtained from mouse models and human disease, its role in physiology and pathophysiology will be reviewed. Future investigations of MR biology should lead to new therapeutic strategies, modulating cell-specific actions in the management of cardiovascular disease, neuroprotection, mineralocorticoid resistance, and metabolic disorders.

MeSH Terms
Animals Brain Diseases/metabolism Cardiovascular Diseases/metabolism Cell Nucleus/metabolism Humans Metabolic Diseases/metabolism Receptors, Mineralocorticoid/metabolism Transcriptional Activation/physiology
Chemicals
Receptors, Mineralocorticoid
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Viengchareun Say
Inserm U693, Le Kremlin-Bicêtre, France.
Le Menuet Damien
Martinerie Laetitia
Munier Mathilde
Pascual-Le Tallec Laurent
Lombès Marc
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Article Info
Journal
Nuclear receptor signaling
Abbr.
Nucl Recept Signal
ISSN
1550-7629
DOI
10.1621/nrs.05012
Published
2007-11-30
Epub
2007-00-30
Pages
e012
Language
English
Region
United States
NLM ID
101237902
PMCID
PMC2121322
Subset
IM
External Links
PubMed source DOI: 10.1621/nrs.05012 PMC Full Text
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