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题目:: T follicular helper (TFH) cells in normal and dysregulated immune responses.
作者:: King(Cecile),Tangye(Stuart G),Mackay(Charles R)
状态:: 发布时间2008-03-28 , 更新时间 2008-03-28
期刊:: Annu Rev Immunol
摘要:: T cell help for antibody production is a fundamental aspect of immune responses. Only recently has a better understanding of the cellular and molecular mechanisms for T cell help emerged. A subset of T cells, termed T follicular helper cells (T(FH) cells), provides a helper function to B cells and represents one of the most numerous and important subsets of effector T cells in lymphoid tissues. T(FH) cells are distinguishable from Th1 and Th2 cells by several criteria, including chemokine receptor expression (CXCR5), location/migration (B cell follicles), and function (B cell help). Central to the function of CD4(+) T cells is IL-21, a "helper" cytokine produced by T(FH) cells that potently stimulates the differentiation of B cells into Ab-forming cells through IL-21R. Consequently, dysregulation of T(FH) cell function, and over- or under-expression of T(FH) cell-associated molecules such as ICOS or IL-21, most likely contributes to the pathogenesis of certain autoimmune diseases or immunodeficiencies.
语言:: eng
DOI:: 10.1146/annurev.immunol.26.021607.090344

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