Abstract
There is relatively little information in the literature on the histopathology of chronic hepatitis C in children. The Peds-C Trial, designed to test the efficacy and safety of peginterferon alfa-2a and ribavirin in children, provided an opportunity to examine liver biopsies from 121 treatment-naïve children, ages 2 to 16 (mean, 9.8 years) infected with the hepatitis C virus (HCV) and with no other identifiable cause for liver disease, signs of hepatic decompensation, or another significant nonhepatic disease. Liver biopsies were scored for inflammation, fibrosis, steatosis, and other histological features. Inflammation in the biopsy was minimal in 42%, mild in 17%, moderate in 38%, and severe in only 3%. Five had bridging fibrosis, and 2 had cirrhosis. Steatosis was absent in 56%, minimal in 34%, and mild in 10%. Inflammation scores correlated with fibrosis scores, serum alanine aminotransferase levels, and duration of infection, but not with age, body mass index z score, or HCV genotype. Fibrosis scores correlated with inflammation but not with age, HCV genotype, body mass index z score, or steatosis parameters. Steatosis correlated with serum alanine aminotransferase levels and body mass index z scores; overweight children had more fibrosis than the non-overweight. In conclusion, in this cohort of HCV-infected children, inflammation, fibrosis, and steatosis were milder than reported for treatment-naïve adults with chronic hepatitis C, but there were several with bridging fibrosis or cirrhosis. The positive correlation of inflammation with duration of infection and fibrosis and of obesity with fibrosis suggest that children with chronic hepatitis C will be at risk for progressive liver disease as they age and possibly acquire other comorbid risk factors.
MeSH Terms
Adolescent
Adult
Biopsy
Child
Child, Preschool
Cohort Studies
Disease Progression
Female
Hepatitis C, Chronic/diagnosis,drug therapy,pathology
Humans
Interferon alpha-2
Interferon-alpha/therapeutic use
Male
Polyethylene Glycols/therapeutic use
Recombinant Proteins
Chemicals
Interferon alpha-2
Interferon-alpha
Recombinant Proteins
Polyethylene Glycols
peginterferon alfa-2a
Authors & Affiliations
15 authors, click to expand affiliations / ORCID
Goodman Zachary D
Armed Forces Institute of Pathology and Veterans Administration Special Reference Laboratory for Pathology, Washington, DC, USA. Goodman@afip.osd.mil
Makhlouf Hala R
Liu Lea
Balistreri William
Gonzalez-Peralta Regino P
Haber Barbara
Jonas Maureen M
Mohan Parvathi
Molleston Jean P
Murray Karen F
Narkewicz Michael R
Rosenthal Philip
Smith Lesley J
Robuck Patricia R
Schwarz Kathleen B
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