| GeneLibs

题目:: Reduction of E-cadherin expression is associated with non-lobular breast carcinomas of basal-like and triple negative phenotype.
作者:: Mahler-Araujo(B),Savage(K),Parry(S),Reis-Filho(J S)
状态:: 发布时间2008-04-28 , 更新时间 2015-11-19
期刊:: J Clin Pathol
摘要:: E-cadherin inactivation in breast cancer has been shown to be strongly associated with lobular breast cancer. However, little is known about the levels of E-cadherin expression according to the breast cancer "molecular" subtypes. The aim of this study was to address the distribution of E-cadherin expression according to the different molecular subtypes of breast cancer.,E-cadherin expression was immunohistochemically analysed in a tissue microarray containing duplicate cores of 245 invasive breast carcinomas, of which 182 cases were of non-lobular histology, using a semi-quantitative scoring system based on the percentage of cells showing membrane immunopositivity.,In non-lobular breast carcinomas, reduced and/or negative E-cadherin expression was significantly associated with lack of oestrogen receptor expression, low levels of CCND1 expression, positivity for cytokeratins 5/6 and 17, epidermal growth factor receptor and caveolins 1 and 2, p53 expression, high MIB-1 proliferation indices, basal-like phenotype and triple negative phenotype.,This study demonstrates that in the group of non-lobular breast cancers, reduction/lack of E-cadherin expression is preferentially found in basal-like breast carcinomas.
语言:: eng
DOI:: 10.1136/jcp.2007.053991

文献库文献相关信息

DataTable pData

联系方式

微信公众号

文献库 文献相关信息

DataTable pData

联系方式

微信公众号

文献库文献相关信息