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PMID: 18097734 Published · ppublish English Journal Article Meta-Analysis

A meta-analysis of DNA repair gene XPC polymorphisms and cancer risk.

Journal of human genetics ·Vol. 53 ·No. 1 ·2008-00-00 ·Pages 18-33

Zhang D, Chen C, Fu X, Gu S, Mao Y, Xie Y, Huang Y, Li Y

Abstract

Polymorphisms (A33512C, C21151T and PAT -/+) of the xeroderma pigmentosum group C (XPC) were shown to contribute to genetic susceptibility to cancer. However, association studies on these polymorphisms in cancer have shown conflicting results. Thus, we performed a meta-analysis. Overall, there was no significant association between 33512C (9,091 patients and 11,553 controls) and cancer risk. No significant association was found in stratification analysis by tumor sites and ethnicities except an elevated lung cancer risk under the recessive genetic model in all subjects [P = 0.04, odds ratio (OR) = 1.20, 95% confidence interval (CI) 1.00-1.45, P (heterogeneity) = 0.88]. There was no significant association between 21151T (5,227 patients and 5,959 controls) and cancer risk in all subjects but an increased cancer risk in Caucasians under the recessive genetic model (P = 0.006, OR = 1.45, 95% CI 1.11-1.90, P (heterogeneity) = 0.75) and homozygote comparison (P = 0.02, OR = 1.41, 95% CI 1.07-1.81, P (heterogeneity) = 0.41). It might be that 21151T increases bladder cancer risk under the recessive genetic model (P = 0.02, OR = 1.49, 95% CI 1.06-2.09, P (heterogeneity) = 0.47) and homozygote comparison (P = 0.02, OR = 1.49, 95% CI 1.05-2.11, P (heterogeneity) = 0.23). There was no significant association between PAT + (4,600 patients and 4,866 controls) and cancer risk in all subjects. An increased cancer risk in Caucasians was found under the recessive genetic model (P = 0.02, OR = 1.20, 95% CI 1.03-1.40, P (heterogeneity) = 0.37) and homozygote comparison (P = 0.008, OR = 1.26, 95% CI 1.06-1.50, P (heterogeneity) = 0.13). The XPC PAT + allele might increase head and neck cancer risk (P = 0.02, OR = 1.29, 95% CI 1.04-1.59, P (heterogeneity) = 0.15). More studies based on larger, stratified, case-control population, especially studies investigate the combined effect of XPC A33512C, C21151T, and PAT, are required to further evaluate the role of these polymorphisms in different cancers.

MeSH Terms
Case-Control Studies DNA Repair/genetics DNA-Binding Proteins/genetics Genetic Predisposition to Disease Humans Neoplasms/genetics Polymorphism, Genetic Risk Factors
Chemicals
DNA-Binding Proteins XPC protein, human
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Zhang Deqiang
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, 200433, People's Republic of China.
Chen Chengwen
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, 200433, People's Republic of China.
Fu Xuping
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, 200433, People's Republic of China.
Gu Shaohua
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, 200433, People's Republic of China.
Mao Yumin
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, 200433, People's Republic of China.
Xie Yi
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, 200433, People's Republic of China.
Huang Yan
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, 200433, People's Republic of China. huangyan@fudan.edu.cn.
Li Yao
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, 200433, People's Republic of China. yaoli@fudan.edu.cn.
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Article Info
Journal
Journal of human genetics
Abbr.
J Hum Genet
ISSN
1434-5161
DOI
10.1007/s10038-007-0215-5
Email
huangyan@fudan.edu.cn
yaoli@fudan.edu.cn
Published
2008-00-00
Epub
2007-00-17
Pages
18-33
Language
English
Region
England
NLM ID
9808008
Subset
IM
External Links
PubMed source DOI: 10.1007/s10038-007-0215-5 View journal details
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