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题目:: The role of cGMP and the rear of the cell in Dictyostelium chemotaxis and cell streaming.
作者:: Veltman(Douwe M),van Haastert(Peter J M)
状态:: 发布时间2007-12-21 , 更新时间 2013-11-21
期刊:: J Cell Sci
摘要:: During chemotaxis, pseudopod extensions lead the cell towards the source of attractant. The role of actin-filled pseudopodia at the front of the cell is well recognized, whereas the function of the rear of the cell in chemotaxis and cell-cell interactions is less well known. Dictyostelium cell aggregation is mediated by outwardly propagating waves of extracellular cAMP that induce chemotaxis and cell-cell contacts, resulting in streams of cells moving towards the aggregation centre. Wild-type cells efficiently retract pseudopodia in the rear of the cell during the rising flank of the cAMP wave and have a quiescent cell posterior. This polarization largely remains during the declining flank, which causes cells to continue their chemotactic movement towards the aggregation centre and to form stable streams of moving cells. The dominance of the leading-edge pseudopod rescues chemotaxis during the rising flank of the wave, but the cells move in random directions after the peak of the wave has passed. As a consequence, cell-cell contacts cannot be maintained, and the cell streams break up. The results show that a quiescent rear of the cell increases the efficiency of directional movement and is essential to maintain stable cell-cell contacts.
语言:: eng
DOI:: 10.1242/jcs.015602

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