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PMID: 18059266 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Psoriasis is associated with increased beta-defensin genomic copy number.

Nature genetics ·Vol. 40 ·No. 1 ·2008-01-00 ·Pages 23-5

Hollox EJ, Huffmeier U, Zeeuwen PL, Palla R, Lascorz J, Rodijk-Olthuis D, van de Kerkhof PC, Traupe H, de Jongh G, den Heijer M, Reis A, Armour JA, Schalkwijk J

Abstract

Psoriasis is a common inflammatory skin disease with a strong genetic component. We analyzed the genomic copy number polymorphism of the beta-defensin region on human chromosome 8 in 179 Dutch individuals with psoriasis and 272 controls and in 319 German individuals with psoriasis and 305 controls. Comparisons in both cohorts showed a significant association between higher genomic copy number for beta-defensin genes and risk of psoriasis.

MeSH Terms
Case-Control Studies Chromosomes, Human, Pair 8 Gene Dosage Genetic Predisposition to Disease Humans Polymorphism, Genetic Polymorphism, Single Nucleotide Psoriasis/genetics beta-Defensins/genetics
Chemicals
DEFB4A protein, human beta-Defensins
Authors & Affiliations
13 authors, click to expand affiliations / ORCID
Hollox Edward J
Department of Genetics, University of Leicester, Leicester LE1 7RH, UK.
Huffmeier Ulrike
Zeeuwen Patrick L J M
Palla Raquel
Lascorz Jesús
Rodijk-Olthuis Diana
van de Kerkhof Peter C M
Traupe Heiko
de Jongh Gys
den Heijer Martin
Reis André
Armour John A L
Schalkwijk Joost
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15 references, click to expand
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Article Info
Journal
Nature genetics
Abbr.
Nat Genet
ISSN
1546-1718
DOI
10.1038/ng.2007.48
Published
2008-01-00
Epub
2007-00-02
Pages
23-5
Language
English
Region
United States
NLM ID
9216904
PMCID
PMC2447885
Subset
IM
Grants
Wellcome Trust · 071024 · United Kingdom
Corrections
CommentIn
PMID: 18163125
External Links
PubMed source DOI: 10.1038/ng.2007.48 PMC Full Text View journal details
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