Nuclear protein kinase of brain: effect of S-100 protein.

Research communications in chemical pathology and pharmacology ·Vol. 13 ·No. 3 ·1976-03-00 ·Pages 489-96

Perumal AS

Abstract

The non-histone chromosomal protein fraction isolated from purified brain nuclei possesses protein kinase activity. 93% of this activity is lost by heating at 80 degrees C for 5 min. cAMP does not affect the reaction, but cGMP is inhibitory. In the presence of S-100, an acidic brain-specific protein, phosphate incorporation is enhanced 3 to 4 fold. Bovine serum albumin has no effect whereas histone inhibits activity.

MeSH Terms

Animals Brain/enzymology,ultrastructure Cell Nucleus/enzymology Chromosomes/metabolism Cyclic AMP/pharmacology Cyclic GMP/pharmacology Histones/pharmacology Hot Temperature In Vitro Techniques Kinetics Male Nerve Tissue Proteins/pharmacology Protein Kinases/metabolism Rats S100 Proteins/pharmacology Serum Albumin, Bovine/pharmacology Transcription, Genetic

Chemicals

Histones Nerve Tissue Proteins S100 Proteins Serum Albumin, Bovine Cyclic AMP Protein Kinases Cyclic GMP

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Perumal A S

Article Info

Journal

Research communications in chemical pathology and pharmacology

Abbr.

Res Commun Chem Pathol Pharmacol

ISSN

0034-5164

Published

1976-03-00

Pages

489-96

Language

English

Region

United States

NLM ID

0244734

Subset

External Links

PubMed source

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Nuclear protein kinase of brain: effect of S-100 protein.

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