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PMID: 180532 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Acceptor proteins in rat androgenic tissue chromatin.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 73 ·No. 6 ·1976-06-00 ·Pages 1954-8

Klyzsejko-Stefanowicz L, Chiu JF, Tsai YH, Hnilica LS

Abstract

Fractionation of chromatin into urea-soluble chromosomal nonhistone proteins (UP), histones (HP), and DNA-associated nonhistone proteins (NP) revealed that the NP fraction from testicular and prostatic chromatin contains organ-specific acceptors for complexes of 5alpha-dihydrotestosterone (17beta-hydroxy-5alpha-androstan-3-one) and its receptor. This acceptor capacity of androgenic tissue chromatin could be transferred to chromatins from non-target tissues with the NP fraction of DNA-associated proteins. Phosphorylation of chromatin enhanced its hormone-receptor binding capacity.

MeSH Terms
Animals Chromatin/metabolism Dihydrotestosterone/metabolism Liver/metabolism Male Pancreas/metabolism Phosphates/metabolism Prostate/metabolism Proteins/metabolism Rats Receptors, Cell Surface Testis/metabolism
Chemicals
Chromatin Phosphates Proteins Receptors, Cell Surface Dihydrotestosterone
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Klyzsejko-Stefanowicz L
Chiu J F
Tsai Y H
Hnilica L S
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29 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.73.6.1954
Published
1976-06-00
Pages
1954-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC430426
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.73.6.1954 PMC Full Text View journal details
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