Protection of Pseudomonas aeruginosa against ciprofloxacin and beta-lactams by homologous alginate.

Antimicrobial agents and chemotherapy ·Vol. 35 ·No. 11 ·1991-11-00 ·Pages 2450-2

Hodges NA, Gordon CA

Abstract

Pseudomonas aeruginosa-derived alginate but no other neutral and negatively charged polysaccharides protected mucoid and nonmucoid strains of that organism against ciprofloxacin, gentamicin, ticarcillin, and ceftazidime. Data indicate that alginate has an intrinsic protective effect which is independent of diffusion, charge, or biofilm phenomena.

MeSH Terms

Alginates/pharmacology Anti-Bacterial Agents/antagonists & inhibitors,pharmacology Ciprofloxacin/antagonists & inhibitors,pharmacology Cystic Fibrosis/microbiology Humans Microbial Sensitivity Tests Polysaccharides/pharmacology Pseudomonas aeruginosa/drug effects beta-Lactams

Chemicals

Alginates Anti-Bacterial Agents Polysaccharides beta-Lactams Ciprofloxacin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Hodges N A

Department of Pharmacy, Brighton Polytechnic, United Kingdom.

Gordon C A

References (12)

12 references, click to expand

The inhibitory effect of sodium alginate on antibiotic activity against mucoid and non-mucoid strains of Pseudomonas aeruginosa.
J Antimicrob Chemother. 1987 Dec;20(6):815-23 PMID: 2964429
Inhibition of tobramycin diffusion by binding to alginate.
Antimicrob Agents Chemother. 1988 Apr;32(4):518-23 PMID: 3132093
Antibiotic interaction and diffusion through alginate and exopolysaccharide of cystic fibrosis-derived Pseudomonas aeruginosa.
J Antimicrob Chemother. 1988 Nov;22(5):667-74 PMID: 3145268
Immunohistopathologic localization of Pseudomonas aeruginosa in lungs from patients with cystic fibrosis. Implications for the pathogenesis of progressive lung deterioration.
Am Rev Respir Dis. 1989 Dec;140(6):1650-61 PMID: 2513765
Reduced susceptibility of a mucoid strain of Pseudomonas aeruginosa to lysis by ticarcillin and piperacillin.
J Antimicrob Chemother. 1989 Oct;24(4):619-21 PMID: 2515190
The penetration of antibiotics into aggregates of mucoid and non-mucoid Pseudomonas aeruginosa.
J Gen Microbiol. 1989 May;135(5):1291-303 PMID: 2516117
Bacterial biofilms in nature and disease.
Annu Rev Microbiol. 1987;41:435-64 PMID: 3318676
Influence of substrate limitation and growth phase on sensitivity to antimicrobial agents.
J Antimicrob Chemother. 1985 Jan;15 Suppl A:7-14 PMID: 3980338
Antibiotic penetration through bacterial capsules and exopolysaccharides.
J Antimicrob Chemother. 1982 Nov;10(5):368-72 PMID: 6217183
Mucoid Pseudomonas aeruginosa and cystic fibrosis: resistance of the mucoid from to carbenicillin, flucloxacillin and tobramycin and the isolation of mucoid variants in vitro.
J Antimicrob Chemother. 1978 May;4(3):233-40 PMID: 97259
The diffusion of beta-lactam antibiotics through mixed gels of cystic fibrosis-derived mucin and Pseudomonas aeruginosa alginate.
J Antimicrob Chemother. 1991 Mar;27(3):285-93 PMID: 1903787
Pathogenesis of the pseudomonas lung lesion in cystic fibrosis.
Chest. 1989 Jul;96(1):158-64 PMID: 2500307

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.35.11.2450

Published

1991-11-00

Pages

2450-2

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC245405

Subset

External Links

PubMed source DOI: 10.1128/AAC.35.11.2450 PMC Full Text View journal details

Analysis Services

Protection of Pseudomonas aeruginosa against ciprofloxacin and beta-lactams by homologous alginate.

Contact

WeChat Official Account