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PMID: 18039134 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Airway smooth muscle in asthma.

Annual review of pathology ·Vol. 3 ·2008-00-00 ·Pages 523-55

Hershenson MB, Brown M, Camoretti-Mercado B, Solway J

Abstract

Airway smooth muscle plays a multifaceted role in the pathogenesis of asthma. We review the current understanding of the contribution of airway myocytes to airway inflammation, airway wall remodeling, and airflow obstruction in this prevalent disease syndrome. Together, these roles make airway smooth muscle an attractive target for asthma therapy.

MeSH Terms

Animals Asthma/etiology,physiopathology Humans Muscle, Smooth/immunology,physiopathology

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Hershenson Marc B

Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI 48109, USA. mhershen@med.umich.edu

Brown Melanie

Camoretti-Mercado Blanca

Solway Julian

Article Info

Journal

Annual review of pathology

Abbr.

Annu Rev Pathol

ISSN

1553-4006

DOI

10.1146/annurev.pathmechdis.1.110304.100213

mhershen@med.umich.edu

Published

2008-00-00

Pages

523-55

Language

English

Region

United States

NLM ID

101275111

Subset

Grants

NHLBI NIH HHS · HL56399 · United States

NIAID NIH HHS · AI56352 · United States

NHLBI NIH HHS · HL79339 · United States

NHLBI NIH HHS · R01 HL079339 · United States

NHLBI NIH HHS · HL79398 · United States

External Links

PubMed source DOI: 10.1146/annurev.pathmechdis.1.110304.100213 View journal details

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Airway smooth muscle in asthma.

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