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题目:: [Clinical significance of interleukin-6 (IL-6) as a prognostic factor of cancer disease].
作者:: Łukaszewicz(Marta),Mroczko(Barbara),Szmitkowski(Maciej)
状态:: 发布时间2007-11-22 , 更新时间 2010-04-01
期刊:: Pol Arch Med Wewn
摘要:: Interleukin-6 (IL-6) is proinflammatory cytokine that produces multifunctional effects. It is also involved in the regulation of immune reactions, hematopoiesis and inflammatory state. Interleukin-6 has been shown to be associated with tumor progression including inhibition of cancer cells apoptosis and stimulation of angiogenesis. Anti-IL-6 therapy is a new strategy in the inflammatory autoimmune diseases and cancer. Clinical studies have shown elevated serum IL-6 concentrations in patients with endometrial cancer, non-small cell lung carcinoma, colorectal cancer, renal cell carcinoma, breast and ovarian cancer. Serum IL-6 levels correlate with tumor stage, and survival of patients. In this article we have focused on a role of IL-6 as a prognostic factor in several malignancies such as colorectal cancer, breast cancer, gastric cancer and pancreatic cancer.
语言:: pol
DOI:

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