Nationwide study of the prevalence, characteristics, and molecular epidemiology of extended-spectrum-beta-lactamase-producing Enterobacteriaceae in France.

Antimicrobial agents and chemotherapy ·Vol. 52 ·No. 2 ·2008-02-00 ·Pages 786-9

Galas M, Decousser JW, Breton N, Godard T, Allouch PY, Pina P, Collège de Bactériologie Virologie Hygiène ColBVH Study Group

Abstract

Among 10,872 isolates of Enterobacteriaceae from a nationwide study of 88 French hospitals in 2005, 169 (1.7%) expressed an extended-spectrum beta-lactamase. The most prevalent species were Escherichia coli (48.5%), Enterobacter aerogenes (23.7%), and Klebsiella pneumoniae (14.8%). Molecular analysis underlined the polyclonal spread of CTX-M-expressing E. coli, primarily isolates of the CTX-M-1 subgroup.

MeSH Terms

Enterobacteriaceae/classification,drug effects,enzymology,genetics Enterobacteriaceae Infections/epidemiology,microbiology Escherichia coli/enzymology,genetics France/epidemiology Microbial Sensitivity Tests Molecular Epidemiology Prevalence beta-Lactam Resistance beta-Lactamases/biosynthesis,classification,genetics beta-Lactams

Chemicals

beta-Lactams beta-lactamase TEM-3 beta-Lactamases

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Galas Muriel

Service d'Hygiène Hospitalière, Centre Hospitalier de Versailles, Le Chesnay, France.

Decousser Jean-Winoc

Breton Nelly

Godard Thierry

Allouch Pierre Yves

Pina Patrick

Collège de Bactériologie Virologie Hygiène (ColBVH) Study Group

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22 references, click to expand

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Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.00906-07

Published

2008-02-00

Epub

2007-00-19

Pages

786-9

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC2224758

Subset

External Links

PubMed source DOI: 10.1128/AAC.00906-07 PMC Full Text View journal details

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Nationwide study of the prevalence, characteristics, and molecular epidemiology of extended-spectrum-beta-lactamase-producing Enterobacteriaceae in France.

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