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题目:: Family history of cancer and risk of lung cancer among nonsmoking Chinese women.
作者:: Zhang(Yawei),Shu(Xiao-Ou),Gao(Yu-Tang),Ji(Bu-Tian),Yang(Gong),Li(Hong Lan),Kilfoy(Briseis),Rothman(Nathaniel),Zheng(Wei),Chow(Wong-Ho)
状态:: 发布时间2007-11-16 , 更新时间 2015-08-13
期刊:: Cancer Epidemiol Biomarkers Prev
摘要:: The relationship between family cancer history in first-degree relatives and risk of lung cancer was evaluated among a population-based cohort of 71,392 female nonsmokers in Shanghai, China. A total of 179 newly diagnosed lung cancer patients were identified during 441,410 person-years of follow-up. Lung cancer risk was not elevated among those with a family history of lung cancer. However, risk of lung cancer was increased among subjects who had two or more first-degree relatives with any type of cancers {rate ratio [RR], 1.95 [95% confidence intervals (95% CI), 1.08-3.54] for two relatives with any cancers and RR, 3.17 [95% CI, 1.00-10.03] for three or more relatives with any cancer}. Having a family history of colorectal cancer (RR, 2.38; 95% CI, 1.21-4.70) and having siblings with stomach cancer (RR, 2.16; 95% CI, 1.01-4.65) and pancreatic cancer (RR, 4.19; 95% CI, 1.04-16.95) were also found to be associated with lung cancer risk. This cohort study indicated a moderate association of lung cancer risk with a family cancer history in general, but not with a family history of lung cancer specifically. The associations were stronger when a sibling, rather than a parent, was affected. The apparent link between lung cancer risk and a family history of colorectal, stomach, and pancreas cancers may be worth further investigation.
语言:: eng
DOI:: 10.1158/1055-9965.EPI-07-0398

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