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PMID: 17991845 Published · ppublish English Comment Journal Article

Comment on "A G protein coupled receptor is a plasma membrane receptor for the plant hormone abscisic acid".

Science (New York, N.Y.) ·Vol. 318 ·No. 5852 ·2007-11-09 ·Pages 914; author reply 914

Johnston CA, Temple BR, Chen JG, Gao Y, Moriyama EN, Jones AM, Siderovski DP, Willard FS

Abstract

Liu et al. (Reports, 23 March 2007, p. 1712) reported that the Arabidopsis thaliana gene GCR2 encodes a seven-transmembrane, G protein-coupled receptor for abscisic acid. We argue that GCR2 is not likely to be a transmembrane protein nor a G protein-coupled receptor. Instead, GCR2 is most likely a plant homolog of bacterial lanthionine synthetases.

MeSH Terms
Abscisic Acid/metabolism Algorithms Amino Acid Sequence Arabidopsis/chemistry,metabolism Arabidopsis Proteins/chemistry,isolation & purification,metabolism GTP-Binding Protein alpha Subunits/metabolism Hydro-Lyases/chemistry,metabolism Models, Molecular Molecular Sequence Data Multienzyme Complexes/chemistry,metabolism Plant Growth Regulators/metabolism Protein Binding Protein Folding Protein Structure, Secondary Protein Structure, Tertiary Receptors, G-Protein-Coupled/chemistry,isolation & purification,metabolism Recombinant Proteins/chemistry,metabolism Sequence Alignment
Chemicals
Arabidopsis Proteins GCR2 protein, Arabidopsis GPA1 protein, Arabidopsis GTP-Binding Protein alpha Subunits Multienzyme Complexes Plant Growth Regulators Receptors, G-Protein-Coupled Recombinant Proteins Abscisic Acid Hydro-Lyases lanthionine synthase
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Johnston Christopher A
Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA.
Temple Brenda R
Chen Jin-Gui
Gao Yajun
Moriyama Etsuko N
Jones Alan M
Siderovski David P
Willard Francis S
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
Published
2007-11-09
Pages
914; author reply 914
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Corrections
CommentOn
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