Home LiteratureArticle Details
PMID: 17975326 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

Prevalence of dementia in the United States: the aging, demographics, and memory study.

Neuroepidemiology ·Vol. 29 ·No. 1-2 ·2007-00-00 ·Pages 125-32

Plassman BL, Langa KM, Fisher GG, Heeringa SG, Weir DR, Ofstedal MB, Burke JR, Hurd MD, Potter GG, Rodgers WL, Steffens DC, Willis RJ, Wallace RB

Abstract

To estimate the prevalence of Alzheimer's disease (AD) and other dementias in the USA using a nationally representative sample. The Aging, Demographics, and Memory Study sample was composed of 856 individuals aged 71 years and older from the nationally representative Health and Retirement Study (HRS) who were evaluated for dementia using a comprehensive in-home assessment. An expert consensus panel used this information to assign a diagnosis of normal cognition, cognitive impairment but not demented, or dementia (and dementia subtype). Using sampling weights derived from the HRS, we estimated the national prevalence of dementia, AD and vascular dementia by age and gender. The prevalence of dementia among individuals aged 71 and older was 13.9%, comprising about 3.4 million individuals in the USA in 2002. The corresponding values for AD were 9.7% and 2.4 million individuals. Dementia prevalence increased with age, from 5.0% of those aged 71-79 years to 37.4% of those aged 90 and older. Dementia prevalence estimates from this first nationally representative population-based study of dementia in the USA to include subjects from all regions of the country can provide essential information for effective planning for the impending healthcare needs of the large and increasing number of individuals at risk for dementia as our population ages.

MeSH Terms
Age Distribution Aged Aged, 80 and over Cohort Studies Dementia/diagnosis,epidemiology Female Geriatric Assessment Health Surveys Humans Logistic Models Male Prevalence Sex Distribution United States/epidemiology
Authors & Affiliations
13 authors, click to expand affiliations / ORCID
Plassman B L
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27701, USA. brenda.plassman@duke.edu
Langa K M
Fisher G G
Heeringa S G
Weir D R
Ofstedal M B
Burke J R
Hurd M D
Potter G G
Rodgers W L
Steffens D C
Willis R J
Wallace R B
References (34)
34 references, click to expand
  1. Clinical and neuropathological criteria for frontotemporal dementia. The Lund and Manchester Groups.
    J Neurol Neurosurg Psychiatry. 1994 Apr;57(4):416-8 PMID: 8163988
  2. Epidemiology, education, and the ecology of Alzheimer's disease.
    Neurology. 1993 Feb;43(2):246-9 PMID: 8437687
  3. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium.
    JAMA. 1997 Oct 22-29;278(16):1349-56 PMID: 9343467
  4. Lack of association between Alzheimer's disease and education, occupation, marital status, or living arrangement.
    Neurology. 1992 Nov;42(11):2063-8 PMID: 1436513
  5. Mild cognitive impairment: clinical characterization and outcome.
    Arch Neurol. 1999 Mar;56(3):303-8 PMID: 10190820
  6. Canadian study of health and aging: study methods and prevalence of dementia.
    CMAJ. 1994 Mar 15;150(6):899-913 PMID: 8131123
  7. The public health impact of Alzheimer's disease, 2000-2050: potential implication of treatment advances.
    Annu Rev Public Health. 2002;23:213-31 PMID: 11910061
  8. The prevalence and 3-year incidence of dementia in older Black and White community residents.
    J Clin Epidemiol. 1998 Jul;51(7):587-95 PMID: 9674666
  9. Regional and racial differences in prevalence of stroke--23 states and District of Columbia, 2003.
    MMWR Morb Mortal Wkly Rep. 2005 May 20;54(19):481-4 PMID: 15902070
  10. The prevalence of dementia: a quantitative integration of the literature.
    Acta Psychiatr Scand. 1987 Nov;76(5):465-79 PMID: 3324647
  11. Comparison of clinical and neuropathologic diagnoses of Alzheimer's disease in 3 epidemiologic samples.
    Alzheimers Dement. 2006 Jan;2(1):2-11 PMID: 19595851
  12. Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset.
    Am J Public Health. 1998 Sep;88(9):1337-42 PMID: 9736873
  13. Epidemiology of Alzheimer's disease.
    Epidemiol Rev. 1992;14:59-82 PMID: 1289117
  14. Incidence of dementia in a population older than 75 years in the United Kingdom.
    Arch Gen Psychiatry. 1994 Apr;51(4):325-32 PMID: 8161293
  15. Alzheimer disease in the US population: prevalence estimates using the 2000 census.
    Arch Neurol. 2003 Aug;60(8):1119-22 PMID: 12925369
  16. Geographic variation in stroke risk in the United States. Region, urbanization, and hypertension in the Third National Health and Nutrition Examination Survey.
    Stroke. 2000 Jan;31(1):19-25 PMID: 10625710
  17. Rates and risk factors for dementia and Alzheimer's disease: results from EURODEM pooled analyses. EURODEM Incidence Research Group and Work Groups. European Studies of Dementia.
    Neurology. 1999 Jan 1;52(1):78-84 PMID: 9921852
  18. The prevalence of dementia in Europe: a collaborative study of 1980-1990 findings. Eurodem Prevalence Research Group.
    Int J Epidemiol. 1991 Sep;20(3):736-48 PMID: 1955260
  19. Incidence and prevalence of dementia in a multiethnic cohort of municipal retirees.
    Neurology. 1997 Jul;49(1):44-50 PMID: 9222168
  20. Recruitment of adults 65 years and older as participants in the Cardiovascular Health Study.
    Ann Epidemiol. 1993 Jul;3(4):358-66 PMID: 8275211
  21. Prevalence of Alzheimer's disease and dementia in two communities: Nigerian Africans and African Americans.
    Am J Psychiatry. 1995 Oct;152(10):1485-92 PMID: 7573588
  22. Asset and Health Dynamics Among the Oldest Old: an overview of the AHEAD Study.
    J Gerontol B Psychol Sci Soc Sci. 1997 May;52 Spec No:1-20 PMID: 9215354
  23. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop.
    Neurology. 1996 Nov;47(5):1113-24 PMID: 8909416
  24. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease.
    Neurology. 1984 Jul;34(7):939-44 PMID: 6610841
  25. APOE-epsilon4 count predicts age when prevalence of AD increases, then declines: the Cache County Study.
    Neurology. 1999 Jul 22;53(2):321-31 PMID: 10430421
  26. Prevalence and severity of cognitive impairment with and without dementia in an elderly population.
    Lancet. 1997 Jun 21;349(9068):1793-6 PMID: 9269213
  27. Prevalence of dementia and probable senile dementia of the Alzheimer type in the Framingham Study.
    Neurology. 1992 Jan;42(1):115-9 PMID: 1734291
  28. Global prevalence of dementia: a Delphi consensus study.
    Lancet. 2005 Dec 17;366(9503):2112-7 PMID: 16360788
  29. Incidence of AD in African-Americans, Caribbean Hispanics, and Caucasians in northern Manhattan.
    Neurology. 2001 Jan 9;56(1):49-56 PMID: 11148235
  30. Incidence and prevalence of dementia in the Cardiovascular Health Study.
    J Am Geriatr Soc. 2004 Feb;52(2):195-204 PMID: 14728627
  31. Education and the prevalence of dementia and Alzheimer's disease.
    Neurology. 1993 Jan;43(1):13-20 PMID: 8423876
  32. The Aging, Demographics, and Memory Study: study design and methods.
    Neuroepidemiology. 2005;25(4):181-91 PMID: 16103729
  33. Is the risk of developing Alzheimer's disease greater for women than for men?
    Am J Epidemiol. 2001 Jan 15;153(2):132-6 PMID: 11159157
  34. Incidence of Alzheimer disease in a biracial urban community: relation to apolipoprotein E allele status.
    Arch Neurol. 2003 Feb;60(2):185-9 PMID: 12580702
Article Info
Journal
Neuroepidemiology
Abbr.
Neuroepidemiology
ISSN
1423-0208
DOI
10.1159/000109998
Email
brenda.plassman@duke.edu
Published
2007-00-00
Epub
2007-00-29
Pages
125-32
Language
English
Region
Switzerland
NLM ID
8218700
PMCID
PMC2705925
Subset
IM
Grants
NIA NIH HHS · K08 AG019180 · United States
NIA NIH HHS · K08 AG019180-05 · United States
NIA NIH HHS · U01 AG009740 · United States
NIA NIH HHS · U01 AG09740 · United States
Corrections
CommentIn
PMID: 17975327
External Links
PubMed source DOI: 10.1159/000109998 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2