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题目:: CD90-positive cells, an additional cell population, produce laminin alpha2 upon transplantation to dy(3k)/dy(3k) mice.
作者:: Fukada(So-Ichiro),Yamamoto(Yukiko),Segawa(Masashi),Sakamoto(Kenta),Nakajima(Mari),Sato(Masaki),Morikawa(Daisuke),Uezumi(Akiyoshi),Miyagoe-Suzuki(Yuko),Takeda(Shin'ichi),Tsujikawa(Kazutake),Yamamoto(Hiroshi)
状态:: 发布时间2007-12-06 , 更新时间 2015-11-19
期刊:: Exp Cell Res
摘要:: Laminin alpha2 is a component of skeletal and cardiac muscle basal lamina. A defect of the laminin alpha2 chain leads to severe congenital muscular dystrophy (MDC1A) in humans and dy/dy mice. Myogenic cells including myoblasts, myotubes, and myofibers in skeletal muscle are a possible source of the laminin alpha2 chain, and myogenic cells are thus proposed as a cell source for congenital muscular dystrophy therapy. However, we observed production of laminin alpha2 in non-myogenic cells of normal mice, and we could enrich these laminin alpha2-producing cells in CD90(+) cell fractions. Intriguingly, the number of CD90(+) cells increased dramatically during skeletal muscle regeneration in mice. This fraction did not include myogenic cells but exhibited a fibroblast-like phenotype. Moreover, these cells were resident in skeletal muscle, not derived from bone marrow. Finally, the production of laminin alpha2 in CD90(+) cells was not dependent on fusion with myogenic cells. Thus, CD90(+) cells are a newly identified additional cell fraction that increased during skeletal muscle regeneration in vivo and could be another cell source for therapy for lama2-deficient muscular dystrophy.
语言:: eng
DOI:: 10.1016/j.yexcr.2007.09.020

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