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题目:: Glia-like stem cells sustain physiologic neurogenesis in the adult mammalian carotid body.
作者:: Pardal(Ricardo),Ortega-Sáenz(Patricia),Durán(Rocío),López-Barneo(José)
状态:: 发布时间2007-10-24 , 更新时间 2016-11-24
期刊:: Cell
摘要:: Neurogenesis is known to occur in the specific niches of the adult mammalian brain, but whether germinal centers exist in the neural-crest-derived peripheral nervous system is unknown. We have discovered stem cells in the adult carotid body (CB), an oxygen-sensing organ of the sympathoadrenal lineage that grows in chronic hypoxemia. Production of new neuron-like CB glomus cells depends on a population of stem cells, which form multipotent and self-renewing colonies in vitro. Cell fate mapping experiments indicate that, unexpectedly, CB stem cells are the glia-like sustentacular cells and can be identified using glial markers. Remarkably, stem cell-derived glomus cells have the same complex chemosensory properties as mature in situ glomus cells. They are highly dopaminergic and produce glial cell line-derived neurotrophic factor. Thus, the mammalian CB is a neurogenic center with a recognizable physiological function in adult life. CB stem cells could be potentially useful for antiparkinsonian cell therapy.
语言:: eng
DOI:: 10.1016/j.cell.2007.07.043

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