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PMID: 17948999 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Redox potential control by drug binding to cytochrome P450 3A4.

Journal of the American Chemical Society ·Vol. 129 ·No. 45 ·2007-11-14 ·Pages 13778-9

Das A, Grinkova YV, Sligar SG

Abstract

暂无摘要

MeSH Terms
Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System/chemistry Nanostructures/chemistry Oxidation-Reduction Spectrophotometry/methods Surface Properties
Chemicals
Cytochrome P-450 Enzyme System Cytochrome P-450 CYP3A CYP3A4 protein, human
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Das Aditi
Department of Biochemistry, School of Molecular and Cellular Biology, University of Illinois, Urbana, Illinois 61801, USA.
Grinkova Yelena V
Sligar Stephen G
References (23)
23 references, click to expand
  1. Lack of electron transfer from cytochrome b5 in stimulation of catalytic activities of cytochrome P450 3A4. Characterization of a reconstituted cytochrome P450 3A4/NADPH-cytochrome P450 reductase system and studies with apo-cytochrome b5.
    J Biol Chem. 1996 Nov 1;271(44):27438-44 PMID: 8910324
  2. Structure and chemistry of cytochrome P450.
    Chem Rev. 2005 Jun;105(6):2253-77 PMID: 15941214
  3. Spin state control of the hepatic cytochrome P450 redox potential.
    Biochem Biophys Res Commun. 1979 Oct 12;90(3):925-32 PMID: 228675
  4. Direct electrochemistry of human, bovine and porcine cytochrome P450c17.
    J Mol Endocrinol. 2006 Apr;36(2):349-59 PMID: 16595705
  5. The redox properties of cytochromes b imposed by the membrane electrostatic environment.
    Biophys J. 1993 Jul;65(1):184-95 PMID: 8396453
  6. Elucidation of distinct ligand binding sites for cytochrome P450 3A4.
    Biochemistry. 2000 May 23;39(20):5929-39 PMID: 10821664
  7. Beef adrenal cortical cytochrome P-450 which catalyzes the conversion of cholesterol to pregnenolone. Oxidation-reduction potentials of the free, steroid-complexed, and adrenodoxin-complexed P-450.
    J Biol Chem. 1981 Jan 10;256(1):343-50 PMID: 7451443
  8. Homotropic cooperativity of monomeric cytochrome P450 3A4 in a nanoscale native bilayer environment.
    Arch Biochem Biophys. 2004 Oct 15;430(2):218-28 PMID: 15369821
  9. Applications of phospholipid bilayer nanodiscs in the study of membranes and membrane proteins.
    Biochemistry. 2007 Feb 27;46(8):2059-69 PMID: 17263563
  10. Oxidation-reduction properties of rat liver cytochromes P-450 and NADPH-cytochrome p-450 reductase related to catalysis in reconstituted systems.
    Biochemistry. 1983 Jun 7;22(12):2811-20 PMID: 6307349
  11. Restoration of high-potential cytochrome b-564 by integration of baker's yeast complex III into liposomes.
    Biochem Biophys Res Commun. 1988 May 16;152(3):981-6 PMID: 2837192
  12. A thermodynamic model of regulation: modulation of redox equilibria in camphor monoxygenase.
    Proc Natl Acad Sci U S A. 1976 Apr;73(4):1078-82 PMID: 1063390
  13. The one-electron autoxidation of human cytochrome P450 3A4.
    J Biol Chem. 2007 Sep 14;282(37):26865-26873 PMID: 17650504
  14. Cytochrome P-450 3A4: regulation and role in drug metabolism.
    Annu Rev Pharmacol Toxicol. 1999;39:1-17 PMID: 10331074
  15. Coupling of spin, substrate, and redox equilibria in cytochrome P450.
    Biochemistry. 1976 Nov 30;15(24):5399-406 PMID: 187215
  16. Cooperativity in cytochrome P450 3A4: linkages in substrate binding, spin state, uncoupling, and product formation.
    J Biol Chem. 2007 Mar 9;282(10):7066-76 PMID: 17213193
  17. Spin-state changes in cytochrome P-450cam on binding of specific substrates.
    Proc Natl Acad Sci U S A. 1970 Aug;66(4):1157-63 PMID: 4319883
  18. Effects of nonpolar environments on the redox potentials of heme complexes.
    Proc Natl Acad Sci U S A. 1972 Aug;69(8):2263-7 PMID: 4506096
  19. The structural basis for substrate-induced changes in redox potential and spin equilibrium in cytochrome P-450CAM.
    Biochemistry. 1989 Jan 24;28(2):917-22 PMID: 2713354
  20. Mössbauer investigations of high-spin ferrous heme proteins. I. Cytochrome P-450.
    Biochemistry. 1975 Sep 23;14(19):4151-8 PMID: 1182094
  21. Redox potentiometry: determination of midpoint potentials of oxidation-reduction components of biological electron-transfer systems.
    Methods Enzymol. 1978;54:411-35 PMID: 732578
  22. The ferrous-dioxygen intermediate in human cytochrome P450 3A4. Substrate dependence of formation and decay kinetics.
    J Biol Chem. 2006 Aug 18;281(33):23313-8 PMID: 16762915
  23. Analysis of human cytochrome P450 3A4 cooperativity: construction and characterization of a site-directed mutant that displays hyperbolic steroid hydroxylation kinetics.
    Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6636-41 PMID: 9618464
Article Info
Journal
Journal of the American Chemical Society
Abbr.
J Am Chem Soc
ISSN
0002-7863
DOI
10.1021/ja074864x
Published
2007-11-14
Epub
2007-00-19
Pages
13778-9
Language
English
Region
United States
NLM ID
7503056
PMCID
PMC2535932
Subset
IM
Grants
NIGMS NIH HHS · R01 GM033775-24 · United States
NIGMS NIH HHS · GM31756 · United States
NIGMS NIH HHS · R37 GM031756 · United States
NIGMS NIH HHS · R01 GM033775 · United States
NIGMS NIH HHS · R01 GM031756 · United States
NIGMS NIH HHS · R37 GM031756-18 · United States
External Links
PubMed source DOI: 10.1021/ja074864x PMC Full Text View journal details
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