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PMID: 17943192 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Which evolutionary processes influence natural genetic variation for phenotypic traits?

Nature reviews. Genetics ·Vol. 8 ·No. 11 ·2007-11-00 ·Pages 845-56

Mitchell-Olds T, Willis JH, Goldstein DB

Abstract

Although many studies provide examples of evolutionary processes such as adaptive evolution, balancing selection, deleterious variation and genetic drift, the relative importance of these selective and stochastic processes for phenotypic variation within and among populations is unclear. Theoretical and empirical studies from humans as well as natural animal and plant populations have made progress in examining the role of these evolutionary forces within species. Tentative generalizations about evolutionary processes across species are beginning to emerge, as well as contrasting patterns that characterize different groups of organisms. Furthermore, recent technical advances now allow the combination of ecological measurements of selection in natural environments with population genetic analysis of cloned QTLs, promising advances in identifying the evolutionary processes that influence natural genetic variation.

MeSH Terms
Animals Evolution, Molecular Genetic Variation Humans Phenotype Quantitative Trait Loci
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Mitchell-Olds Thomas
Department of Biology, BOX 90338, Duke University, Durham, North Carolina 27708, USA. tmo1@duke.edu
Willis John H
Goldstein David B
Article Info
Journal
Nature reviews. Genetics
Abbr.
Nat Rev Genet
ISSN
1471-0064
Published
2007-11-00
Pages
845-56
Language
English
Region
England
NLM ID
100962779
Subset
IM
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