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PMID: 17938233 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A constant affinity threshold for T cell tolerance.

The Journal of experimental medicine ·Vol. 204 ·No. 11 ·2007-10-29 ·Pages 2553-9

Naeher D, Daniels MA, Hausmann B, Guillaume P, Luescher I, Palmer E

Abstract

T cell tolerance depends on the T cell receptor's affinity for peptide/major histocompatibility complex (MHC) ligand; this critical parameter determines whether a thymocyte will be included (positive selection) or excluded (negative selection) from the T cell repertoire. A quantitative analysis of ligand binding was performed using an experimental system permitting receptor-coreceptor interactions on live cells under physiological conditions. Using three transgenic mouse strains expressing distinct class I MHC-restricted T cell receptors, we determined the affinity that defines the threshold for negative selection. The affinity threshold for self-tolerance appears to be a constant for cytotoxic T lymphocytes.

MeSH Terms
Antigens, CD/immunology Antigens, Differentiation, T-Lymphocyte/immunology CD4 Antigens/immunology CD4-Positive T-Lymphocytes/immunology CD8 Antigens/immunology CD8-Positive T-Lymphocytes Down-Regulation Histocompatibility Antigens Class I/immunology Humans Immune Tolerance Lectins, C-Type Lymphocyte Activation Receptors, Antigen, T-Cell/genetics,immunology T-Lymphocytes/immunology T-Lymphocytes, Cytotoxic/immunology Thymus Gland/immunology
Chemicals
Antigens, CD Antigens, Differentiation, T-Lymphocyte CD4 Antigens CD69 antigen CD8 Antigens Histocompatibility Antigens Class I Lectins, C-Type Receptors, Antigen, T-Cell
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Naeher Dieter
Laboratory of Transplantation Immunology, Department of Research, University Hospital, 4031 Basel, Switzerland.
Daniels Mark A
Hausmann Barbara
Guillaume Philippe
Luescher Immanuel
Palmer Ed
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
1540-9538
DOI
10.1084/jem.20070254
Published
2007-10-29
Epub
2007-00-15
Pages
2553-9
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2118488
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.20070254 PMC Full Text View journal details
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