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PMID: 17933887 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

YhbO protects cells against multiple stresses.

Journal of bacteriology ·Vol. 189 ·No. 24 ·2007-12-00 ·Pages 9140-4

Abdallah J, Caldas T, Kthiri F, Kern R, Richarme G

Abstract

YhbO is a member of the DJ-1/ThiJ/Pfp1 superfamily, which includes chaperones, peptidases, and the Parkinson's disease protein DJ-1. A yhbO-disrupted mutant of Escherichia coli is highly sensitive to oxidative, thermal, UV, and pH stresses, and the putative nucleophilic cysteine C104 of YhbO is required for stress resistance. These results suggest that YhbO affects a central process in stress management.

MeSH Terms
Anti-Bacterial Agents/pharmacology Cysteine/genetics Escherichia coli/drug effects,genetics,physiology,radiation effects Escherichia coli Proteins/genetics,physiology Heat-Shock Proteins/genetics,physiology Hot Temperature Hydrogen-Ion Concentration Mutagenesis, Insertional Oxidants/pharmacology Ultraviolet Rays
Chemicals
Anti-Bacterial Agents Escherichia coli Proteins Heat-Shock Proteins Oxidants YhbO protein, E coli Cysteine
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Abdallah Jad
Stress Molecules, Institut Jacques Monod, Université Paris 7, 2 Place Jussieu, 75005 Paris, France.
Caldas Teresa
Kthiri Fatoum
Kern Renée
Richarme Gilbert
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
1098-5530
DOI
10.1128/JB.01208-07
Published
2007-12-00
Epub
2007-00-12
Pages
9140-4
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC2168597
Subset
IM
External Links
PubMed source DOI: 10.1128/JB.01208-07 PMC Full Text View journal details
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