[Determination of nystatin component composition using HPLC and TLC with densitometry].

Opredelenie komponentnogo sostava nistatina metodami VEZhKh i TSKh s ispol'zovaniem densitometrii.

Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] ·Vol. 36 ·No. 11 ·1991-11-00 ·Pages 9-11

Mitrofanova VG, Shenin IuD, Mirgorodskaia OA, Derzhavets AA, Matveeva ER, Grinberg GE, Apter IuM, Golubkova LS

Abstract

The component composition of nystatin produced by an improved strain of Streptomyces noursei was determined by HPLC on Milichrom chromatograph (USSR). It was shown that the antibiotic consisted of nystatins A1, A2, A3 and B and admixture substances. The data appeared to be in good agreement with the results of the complex TLC investigation, by using densitometry. The component composition of the samples was evidenced by SIEAP mass spectrometry. Physiochemical and biological characteristics of separate components are presented.

MeSH Terms

Chromatography, High Pressure Liquid Chromatography, Thin Layer Densitometry Nystatin/analysis

Chemicals

Nystatin

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Mitrofanova V G

Shenin Iu D

Mirgorodskaia O A

Derzhavets A A

Matveeva E R

Grinberg G E

Apter Iu M

Golubkova L S

Article Info

Journal

Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]

Abbr.

Antibiot Khimioter

ISSN

0235-2990

Published

1991-11-00

Pages

9-11

Language

rus

Region

Russia (Federation)

NLM ID

8803688

Subset

External Links

PubMed source

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[Determination of nystatin component composition using HPLC and TLC with densitometry].

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