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PMID: 17913492 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Review

Sensor complexes regulating two-component signal transduction.

Current opinion in structural biology ·Vol. 17 ·No. 6 ·2007-12-00 ·Pages 706-15

Szurmant H, White RA, Hoch JA

Abstract

Two-component signal transduction systems consisting of a sensor histidine kinase and a response regulator/transcription factor interpret a multitude of environmental and cellular signals and coordinate the expression of a wide array of genes in bacteria. Signal recognition by sensor histidine kinases is the province of a sensor complex consisting of several protein domains that together serve to augment or attenuate the activity of the histidine kinase and thereby of gene expression. Recent investigations have shown the diverse strategies bacteria use to assemble protein domains into the sensor complexes to accomplish signaling. Structural studies of such domains are leading to an understanding of the mechanisms by which sensor complexes recognize signals and regulate kinase activity.

MeSH Terms
Catalytic Domain Cytoplasm/metabolism Models, Molecular Proteins/metabolism Signal Transduction
Chemicals
Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Szurmant Hendrik
The Scripps Research Institute, Division of Cellular Biology, Mail Code: MEM-116, Department of Molecular and Experimental Medicine, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. szurmant@scripps.edu
White Robert A
Hoch James A
References (48)
48 references, click to expand
  1. Anthrax.
    Annu Rev Microbiol. 2001;55:647-71 PMID: 11544370
  2. Chemical communication in proteobacteria: biochemical and structural studies of signal synthases and receptors required for intercellular signalling.
    Mol Microbiol. 2004 Aug;53(3):755-69 PMID: 15255890
  3. Structure of the entire cytoplasmic portion of a sensor histidine-kinase protein.
    EMBO J. 2005 Dec 21;24(24):4247-59 PMID: 16319927
  4. The structure of the periplasmic ligand-binding domain of the sensor kinase CitA reveals the first extracellular PAS domain.
    J Biol Chem. 2003 Oct 3;278(40):39189-96 PMID: 12867417
  5. Crystal structure and interactions of the PAS repeat region of the Drosophila clock protein PERIOD.
    Mol Cell. 2005 Jan 7;17(1):69-82 PMID: 15629718
  6. Structure of the GAF domain, a ubiquitous signaling motif and a new class of cyclic GMP receptor.
    EMBO J. 2000 Oct 16;19(20):5288-99 PMID: 11032796
  7. Resonance Raman analysis of the Pr and Pfr forms of phytochrome.
    Biochemistry. 1990 Dec 18;29(50):11141-6 PMID: 2271702
  8. YycH regulates the activity of the essential YycFG two-component system in Bacillus subtilis.
    J Bacteriol. 2005 Aug;187(15):5419-26 PMID: 16030236
  9. Characterization of sporulation histidine kinases of Bacillus anthracis.
    J Bacteriol. 2005 Oct;187(20):6972-81 PMID: 16199567
  10. Regulation of Salmonella typhimurium virulence gene expression by cationic antimicrobial peptides.
    Mol Microbiol. 2003 Oct;50(1):219-30 PMID: 14507376
  11. Metal bridges between the PhoQ sensor domain and the membrane regulate transmembrane signaling.
    J Mol Biol. 2006 Mar 10;356(5):1193-206 PMID: 16406409
  12. Structural identification of a bacterial quorum-sensing signal containing boron.
    Nature. 2002 Jan 31;415(6871):545-9 PMID: 11823863
  13. The NMR structure of the sensory domain of the membranous two-component fumarate sensor (histidine protein kinase) DcuS of Escherichia coli.
    J Biol Chem. 2003 Oct 3;278(40):39185-8 PMID: 12907689
  14. Structure of the NCoA-1/SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain.
    J Mol Biol. 2004 Feb 13;336(2):319-29 PMID: 14757047
  15. Mutational analysis of a conserved signal-transducing element: the HAMP linker of the Escherichia coli nitrate sensor NarX.
    J Bacteriol. 2003 Jan;185(1):89-97 PMID: 12486044
  16. The HAMP domain structure implies helix rotation in transmembrane signaling.
    Cell. 2006 Sep 8;126(5):929-40 PMID: 16959572
  17. Ligand-induced asymmetry in histidine sensor kinase complex regulates quorum sensing.
    Cell. 2006 Sep 22;126(6):1095-108 PMID: 16990134
  18. Novel domains of the prokaryotic two-component signal transduction systems.
    FEMS Microbiol Lett. 2001 Sep 11;203(1):11-21 PMID: 11557134
  19. Molecular basis of the magnesium deprivation response in Salmonella typhimurium: identification of PhoP-regulated genes.
    J Bacteriol. 1996 Sep;178(17):5092-9 PMID: 8752324
  20. Sterically locked synthetic bilin derivatives and phytochrome Agp1 from Agrobacterium tumefaciens form photoinsensitive Pr- and Pfr-like adducts.
    J Biol Chem. 2005 Jul 1;280(26):24491-7 PMID: 15878872
  21. Quorum sensing in vibrios: complexity for diversification.
    Int J Med Microbiol. 2006 Apr;296(2-3):61-71 PMID: 16487746
  22. Phylogenetic analysis of the phytochrome superfamily reveals distinct microbial subfamilies of photoreceptors.
    Biochem J. 2005 Nov 15;392(Pt 1):103-16 PMID: 16004604
  23. Sensor domains encoded in Bacillus anthracis virulence plasmids prevent sporulation by hijacking a sporulation sensor histidine kinase.
    J Bacteriol. 2006 Sep;188(17):6354-60 PMID: 16923903
  24. Cache - a signaling domain common to animal Ca(2+)-channel subunits and a class of prokaryotic chemotaxis receptors.
    Trends Biochem Sci. 2000 Nov;25(11):535-7 PMID: 11084361
  25. The cytoplasmic helical linker domain of receptor histidine kinase and methyl-accepting proteins is common to many prokaryotic signalling proteins.
    FEMS Microbiol Lett. 1999 Jul 1;176(1):111-6 PMID: 10418137
  26. Atomic structure and specificity of bacterial periplasmic receptors for active transport and chemotaxis: variation of common themes.
    Mol Microbiol. 1996 Apr;20(1):17-25 PMID: 8861200
  27. The crystal structure of YycH involved in the regulation of the essential YycFG two-component system in Bacillus subtilis reveals a novel tertiary structure.
    Protein Sci. 2006 Apr;15(4):929-34 PMID: 16600972
  28. A census of membrane-bound and intracellular signal transduction proteins in bacteria: bacterial IQ, extroverts and introverts.
    BMC Microbiol. 2005 Jun 14;5:35 PMID: 15955239
  29. Structure of the oxygen sensor in Bacillus subtilis: signal transduction of chemotaxis by control of symmetry.
    Structure. 2003 Sep;11(9):1097-110 PMID: 12962628
  30. Mutations in tar suppress defects in maltose chemotaxis caused by specific malE mutations.
    J Bacteriol. 1986 Jan;165(1):34-40 PMID: 3510191
  31. Regulation of LuxPQ receptor activity by the quorum-sensing signal autoinducer-2.
    Mol Cell. 2005 May 27;18(5):507-18 PMID: 15916958
  32. The crystal structure of Bacillus subtilis YycI reveals a common fold for two members of an unusual class of sensor histidine kinase regulatory proteins.
    J Bacteriol. 2007 Apr;189(8):3290-5 PMID: 17307848
  33. The phosphatase activity is the target for Mg2+ regulation of the sensor protein PhoQ in Salmonella.
    J Biol Chem. 2000 Jul 28;275(30):22948-54 PMID: 10807931
  34. Pfam: clans, web tools and services.
    Nucleic Acids Res. 2006 Jan 1;34(Database issue):D247-51 PMID: 16381856
  35. Stimulus perception in bacterial signal-transducing histidine kinases.
    Microbiol Mol Biol Rev. 2006 Dec;70(4):910-38 PMID: 17158704
  36. PAS: a multifunctional domain family comes to light.
    Curr Biol. 1997 Nov 1;7(11):R674-7 PMID: 9382818
  37. Characterization of the catalytic activities of the PhoQ histidine protein kinase of Salmonella enterica serovar Typhimurium.
    J Bacteriol. 2001 Mar;183(5):1787-91 PMID: 11160113
  38. The GAF domain: an evolutionary link between diverse phototransducing proteins.
    Trends Biochem Sci. 1997 Dec;22(12):458-9 PMID: 9433123
  39. High resolution structure of Deinococcus bacteriophytochrome yields new insights into phytochrome architecture and evolution.
    J Biol Chem. 2007 Apr 20;282(16):12298-309 PMID: 17322301
  40. A light-sensing knot revealed by the structure of the chromophore-binding domain of phytochrome.
    Nature. 2005 Nov 17;438(7066):325-31 PMID: 16292304
  41. Two-component and phosphorelay signal transduction.
    Curr Opin Microbiol. 2000 Apr;3(2):165-70 PMID: 10745001
  42. Transmembrane signal transduction and osmoregulation in Escherichia coli: functional importance of the transmembrane regions of membrane-located protein kinase, EnvZ.
    J Biochem. 1992 Jun;111(6):707-13 PMID: 1323560
  43. YycH and YycI interact to regulate the essential YycFG two-component system in Bacillus subtilis.
    J Bacteriol. 2007 Apr;189(8):3280-9 PMID: 17307850
  44. A piston model for transmembrane signaling of the aspartate receptor.
    Science. 1999 Sep 10;285(5434):1751-4 PMID: 10481014
  45. Myoglobin-like aerotaxis transducers in Archaea and Bacteria.
    Nature. 2000 Feb 3;403(6769):540-4 PMID: 10676961
  46. Three-dimensional structures of the ligand-binding domain of the bacterial aspartate receptor with and without a ligand.
    Science. 1991 Nov 29;254(5036):1342-7 PMID: 1660187
  47. Recognition of antimicrobial peptides by a bacterial sensor kinase.
    Cell. 2005 Aug 12;122(3):461-72 PMID: 16096064
  48. FFAS03: a server for profile--profile sequence alignments.
    Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W284-8 PMID: 15980471
Article Info
Journal
Current opinion in structural biology
Abbr.
Curr Opin Struct Biol
ISSN
0959-440X
DOI
10.1016/j.sbi.2007.08.019
Email
szurmant@scripps.edu
Published
2007-12-00
Epub
2007-00-29
Pages
706-15
Language
English
Region
England
NLM ID
9107784
PMCID
PMC2175030
Subset
IM
Grants
NIGMS NIH HHS · R37 GM019416 · United States
NIAID NIH HHS · R01 AI055860 · United States
NIGMS NIH HHS · R01 GM019416 · United States
NIGMS NIH HHS · GM019416 · United States
NIGMS NIH HHS · R01 GM019416-35 · United States
NIGMS NIH HHS · F32 GM019416 · United States
NIAID NIH HHS · AI055860 · United States
NIAID NIH HHS · R01 AI055860-05 · United States
External Links
PubMed source DOI: 10.1016/j.sbi.2007.08.019 PMC Full Text View journal details
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